GLP1R Protein, Human, Recombinant (hFc Tag)

GLP1R Protein, Human, Recombinant (hFc Tag): 製品情報

純度
> 95 % as determined by SDS-PAGE.
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
活性
Testing in progress
タンパク質の構築
A DNA sequence encoding the human GLP1R (NP_002053.3) (Met1-Tyr145) was expressed with the Fc region of human IgG1 at the C-terminus.
NP No.
発現ホスト
HEK293 Cells
Human
予測N末端
Arg 24
分子量
The recombinant human GLP1R consists of 360 amino acids and predicts a molecular mass of 41 kDa. As a result of glycosylation, it migrates as an approximately 52.3 kDa band in SDS-PAGE under reducing conditions.
バッファー
Lyophilized from sterile PBS, pH 7.4.
Please contact us for any concerns or special requirements.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
配送
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
安定性 & 保存条件
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
再構成
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

GLP1R Protein, Human, Recombinant (hFc Tag): 画像

GLP1R 背景情報

Glucagon-like peptide (GLP)-1 receptor is encoded by GLP1R. GLP1R plays a critical role in mediating the biological actions of GLP1 in mammals and fish. The neuronal GLP1Rs mediate body weight and anorectic effects of liraglutide, but are not required for glucose-lowering effects. Glucagon-like peptide 1 receptor (GLP1R) signaling has been shown to have antipsychotic properties in animal models and to impact glucose-dependent insulin release, satiety, memory, and learning in man. Glucagon-like peptide-1 receptor (GLP1R) and glucose-dependent insulinotropic peptide receptor (GIPR) are their indirect drug targets.
完全な名称
glucagon-like peptide 1 receptor
  • Prolonged half-life of small-sized therapeutic protein using serum albumin-specific protein binder
    Author
    Kim, TY;Park, JH;Shim, HE;Choi, DS;Lee, DE;Song, JJ;Kim, HS;
    Year
    2019
    Journal
    J Control Release
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