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NCAM1 / CD56
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NCAM1 / CD56 サマリー & タンパク質情報

NCAM1 / CD56 関連情報

NCAM1 / CD56 背景

細胞内位置: Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Cell membrane; Single-pass type I membrane protein.; Isoform 3: Cell membrane; Lipid-anchor, GPI-anchor.; Isoform 4: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.; Isoform 5: Secreted.; Isoform 6: Secreted {ECO:0000305}.
シーケンスの類似性: Contains 2 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.; Contains 5 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
General information above from UniProt

NCAM1, also known as CD56, is a neural adhesion protein (NCAM) which belongs to the immunoglobulin superfamily. NCAM is involved in neural development and in plasticity in the adult brain. UCHL1 is a novel interaction partner of both NCAM isoforms that regulates their ubiquitination and intracellular trafficking. NCAM1 is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. NCAM1 has also been shown to be involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance.

NCAM1 / CD56 代替名

CD56,NCAM,MSK39, [homo-sapiens]
neural cell adhesion molecule 1,NCAM1,CD56,MSK39,NCAM,antigen recognized by monoclonal antibody 5.1H11,neural cell adhesion molecule, [human]
neural cell adhesion molecule 1,Ncam1,CD56,E-NCAM,NCAM-1,Ncam,N-CAM-1, [mouse]
CD56,Ncam,E-NCAM,NCAM-1, [mus-musculus]

NCAM1 / CD56 関連研究

  • Reyes AA. et al., 1991, Mol Cell Biol. 11 (3): 1654-61.
  • Suzuki M. et al., 2003, J Biol Chem. 278 (49): 49459-68.
  • Becker C G. et al., 1996, J Neurosci Res. 45 (2): 143-52.
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