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ラット CLEC4D  タンパク質

All CLEC4D Reagents

発現宿主: Human Cells  
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CLEC4D 関連経路

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    CLEC4D サマリー & タンパク質情報

    CLEC4D 背景

    遺伝子の概要: This CLEC4D gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This CLEC4D gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
    General information above from NCBI
    細胞内位置: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
    組織特異性: Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma. {ECO:0000269|PubMed:14971047}.
    誘導: By autocrine inflammatory stimuli. {ECO:0000269|PubMed:14971047}.
    シーケンスの類似性: Contains 1 C-type lectin domain. {ECO:0000255|PROSITE-ProRule:PRU00040}.
    General information above from UniProt

    C-type lectin (CLEC) family is a type of carbohydrate-binding protein domain named lectin. C-type lectins are the most diverse and prevalent lectin family in immunity with its requirement for calcium for binding. Proteins including a C-type lectin domain have diverse range of functions including cell-cell adhesion, immune response to pathogens and apoptosis. There are at least 14 types of C-type lectins: typeⅠto typeⅩⅣ. CLEC4D(CLECSF8) is a typeⅡ membrane glycoprotein belonging to the C-type lectin family, with restricted expression in the monocyte/macrophage lineage. It plays important roles in the function of macrophages.

    CLEC4D 代替名

    MCL,MPCL,CLEC6,CLEC-6,CLECSF8, [homo-sapiens]
    CLEC4D,MPCL,CLEC6,CLEC-6,CLECSF8,MCL,MGC40078, [human]
    Clec4d,Clecsf8,mcl,MGC117678,Mpcl, [mouse]
    mcl,Mpcl,Clecsf8, [mus-musculus]

    CLEC4D 関連研究

  • Johnson KD, et al. (2007) Friend of GATA-1-independent Transcriptional Repression: A Novel Mode of GATA-1 Function. Blood. 109 (12): 5230-3.
  • Arce I, et al. (2004) The human C-type lectin CLECSF8 is a novel monocyte/macrophage endocytic receptor. Eur J Immunol. 34 (1): 210-20.
  • Marshall AS, et al. (2006) Human MICL (CLEC12A) is differentially glycosylated and is down-regulated following cellular activation. Eur J Immunol. 36 (8): 2159-69.
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