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CCR5 サマリー & タンパク質情報

CCR5 関連情報

CCR5 背景

サブユニット構造: Interacts with PRAF2. Interacts with HIV-1 surface protein gp120. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and ARRB2. Interacts with human cytomegalovirus/HHV-5 protein UL78. {ECO:0000269|PubMed:10085131, ECO:0000269|PubMed:11448957, ECO:0000269|PubMed:11733580, ECO:0000269|PubMed:15757671, ECO:0000269|PubMed:16144840, ECO:0000269|PubMed:21763489, ECO:0000269|PubMed:22496149, ECO:0000269|PubMed:8663314, ECO:0000269|PubMed:8699119, ECO:0000269|PubMed:9632396}.
細胞内位置: Cell membrane {ECO:0000269|PubMed:11323418}; Multi-pass membrane protein {ECO:0000269|PubMed:11323418}.
組織特異性: Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung. {ECO:0000269|PubMed:8639485, ECO:0000269|PubMed:8663314}.
翻訳後: Sulfated on at least 2 of the N-terminal tyrosines. Sulfation contributes to the efficiency of HIV-1 entry and is required for efficient binding of the chemokines, CCL3 and CCL4. {ECO:0000269|PubMed:10089882, ECO:0000269|PubMed:11733580, ECO:0000269|PubMed:21763489}.; O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen. {ECO:0000269|PubMed:10089882, ECO:0000269|PubMed:11733580}.; Palmitoylation in the C-terminal is important for cell surface expression, and to a lesser extent, for HIV entry. {ECO:0000269|PubMed:11323418}.; Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES. {ECO:0000269|PubMed:10085131}.
疾患関連性: DISEASE: Diabetes mellitus, insulin-dependent, 22 (IDDM22) [MIM:612522]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269|PubMed:19073967}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
シーケンスの類似性: Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
General information above from UniProt

CCR5 代替名

CKR5,CCR-5,CD195,CKR-5,CCCKR5,CMKBR5,IDDM22,CC-CKR-5, [homo-sapiens]
AM4-7,CD195,Cmkbr5, [mus-musculus]

CCR5 関連研究