Text Size:AAA

ラット B7-H3/CD276  抗体

All CD276 Reagents

反応度: Rat  
アプリケーション: ELISA  
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    反応度: Rat  
    アプリケーション: ELISA  WB  IP  
    • Slide 1
    • Slide 1
    50 µg 
    200 µg 
    100 µg 
    Add to Cart

    Browse B7-H3/CD276 Products by

    B7-H3/CD276 Related Area

    B7-H3/CD276 関連経路

      B7-H3/CD276 関連製品

      B7-H3/CD276 関連製品

      Featured Reagent Products

      B7-H3/CD276 サマリー & タンパク質情報

      B7-H3/CD276 背景

      遺伝子の概要: The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
      General information above from NCBI
      サブユニット構造: Interacts with TREML2 and this interaction enhances T- cell activation.
      細胞内位置: Membrane; Single-pass type I membrane protein (Probable).
      組織特異性: Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta.
      誘導: By bacterial lipopolysaccharides (LPS) in monocytes and by ionomycin in T and B-lymphocytes. Up-regulated in cells mediating rejection of human transplants.
      シーケンスの類似性: Belongs to the immunoglobulin superfamily. BTN/MOG family.
      Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 2 Ig-like V-type (immunoglobulin-like) domains.
      General information above from UniProt

      B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to either promote or inhibit T-cell responses in various experimental systems. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is a novel protein structurally related to the B7 family of ligands by the presence of a single set of immunoglobulin-V-like and immunoglobulin-C-like (VC) domains. Previous studies have correlated its overexpression with poor prognosis and decreased tumor-infiltrating lymphocytes in various carcinomas including uterine endometrioid carcinomas, and mounting evidence supports an immuno-inhibitory role in ovarian cancer prognosis. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity.

      Immune Checkpoint
      Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
      Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

      Immunotherapy   Cancer Immunotherapy   Targeted Therapy

      B7-H3/CD276 代替名

      B7-H3/CD276 関連研究

    • Suh WK, et al. (2004) The immune regulatory protein B7-H3 promotes osteoblast differentiation and bone mineralization. Proc Natl Acad Sci U S A. 101(35): 12969-73.
    • Waschbisch A, et al. (2008) Human muscle cells express the costimulatory molecule B7-H3, which modulates muscle-immune interactions. Arthritis Rheum. 58(11): 3600-8.
    • Loos M, et al. (2010) B7-h3 and its role in antitumor immunity. Clin Dev Immunol. 2010: 683875.
    • Zang X, et al. (2010) Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas. Mod Pathol. 23(8): 1104-12.
    • Sun J, et al. (2010) Clinical significance and regulation of the costimulatory molecule B7-H3 in human colorectal carcinoma. Cancer Immunol Immunother. 59(8): 1163-71.
    • 注意:すべての製品は、"研究目的のみに使用するものであり、診断または治療目的に使用するものではありません"