MMP-3 Matched ELISA Antibody Pair Set,Human

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MMP-3 Matched ELISA Antibody Pair Set,Human 製品情報

製品名
MMP-3 Matched ELISA Antibody Pair Set,Human
検出原理
Solid Phase Sandwich ELISA
特異性
Quantitative determination of Human MMP-3
線形範囲
31.25-2000 pg/mL
ELISA 抗体ペアセット(すぐに使用できません)の成分
1. Capture Antibody 0.3 mg/mL of mouse anti-Human MMP-3 / MMP3 monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 2 μg/mL in PBS before coating. (Catalog: # 10467-MM02)
2. Detection Antibody 0.2 mg/mL of mouse anti-Human MMP-3 / MMP3 monoclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4, store at 4℃). Dilute to working concentration of 0.5 μg/mL in detection antibody dilution buffer before use. (Catalog: # 10467-MM05)
3. Standard Each vial contains 174 ng of recombinant Human MMP-3 / MMP3. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 2000 pg/mL is recommended.
製品概要
This MMP-3 Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human MMP-3 . It contains Human MMP-3 capture antibody, Human MMP-3 detector antibody (HRP) and a highly purified E. coli-expressed recombinant Human MMP-3 protein. This Pair Set is at affordable price for researchers.
配送方法
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
保存条件
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

MMP-3 Matched ELISA Antibody Pair Set,Human の画像

MMP-3 Matched ELISA Antibody Pair Set,Human: 別名

CHDS6 Matched ELISA Antibody Pair Set, Human; MMP-3 Matched ELISA Antibody Pair Set, Human; SL-1 Matched ELISA Antibody Pair Set, Human; STMY Matched ELISA Antibody Pair Set, Human; STMY1 Matched ELISA Antibody Pair Set, Human; STR1 Matched ELISA Antibody Pair Set, Human

MMP-3 背景情報

Matrix metallopeptidase 3 (abbreviated as MMP3) is also known as stromelysin 1 and progelatinase. MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes including arthritis and metastasis. As a secreted zinc-dependent endopeptidase, MMP3 exerts its functions mainly in extracellular matrix. This protein is activated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMP3 plays a central role in degrading collagen types II, III, IV, IX, and X, proteoglycans, fibronectin, laminin, and elastin. In addition, MMP3 can also active other MMPs such as MMP1, MMP7, and MMP9, rendering MMP3 crucial in connective tissue remodeling. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.
完全な名称
matrix metallopeptidase 3
Related Pathways
  • IL17 signaling pathway
    IL17 signaling pathway
参考文献
  • Sternlicht MD, et al. 1999, The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Cell. 98(2): 137-46.
  • Yoon S, et al. (1999) Genetic analysis of MMP3, MMP9, and PAI-1 in Finnish patients with abdominal aortic or intracranial aneurysms. Biochem Biophys Res Commun. 265(2): 563-8.
  • Biondi ML, et al. (2000) MMP1 and MMP3 polymorphisms in promoter regions and cancer. Clin Chem. 46(12): 2023-4.
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