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マウス CD155/PVR  タンパク質

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CD155/PVR
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発現宿主: Human Cells  
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製品の説明: Active  
発現宿主: Human Cells  
50259-M08H-50
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CD155/PVR 関連経路

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    CD155/PVR サマリー & タンパク質情報

    CD155/PVR 背景

    遺伝子の概要: The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.
    General information above from NCBI
    触媒活性: 0
    補因子: 0
    酵素調節: 0
    サブユニット構造: Can form trans-heterodimers with NECTIN3. The extracellular domain interacts with VTN, CD226 and CD96. The cytoplasmic domain interacts with DYNLT1. Binds with high affinity to TIGIT. {ECO:0000269|PubMed:11437656, ECO:0000269|PubMed:11751937, ECO:0000269|PubMed:12759359, ECO:0000269|PubMed:15034010, ECO:0000269|PubMed:15039383, ECO:0000269|PubMed:15194795, ECO:0000269|PubMed:16216929, ECO:0000269|PubMed:19011627, ECO:0000269|PubMed:22421438}.; (Microbial infection) Interacts with poliovirus capsid proteins. {ECO:0000269|PubMed:2538245}.; (Microbial infection) Interacts with human cytomegalovirus /HHV-5 UL141 protein. {ECO:0000269|PubMed:15640804}.; (Microbial infection) Interacts with pseudorabies virus gD protein. {ECO:0000269|PubMed:9616127}.
    ドメイン: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. {ECO:0000269|PubMed:1851992}.
    細胞内位置: Isoform Alpha: Cell membrane; Single-pass type I membrane protein.; Isoform Delta: Cell membrane; Single-pass type I membrane protein.; Isoform Beta: Secreted.; Isoform Gamma: Secreted.
    組織特異性: 0
    発生段階: 0
    誘導: MUTAGEN 369 372 KCSR->ACSA: Partial loss of DYNLT1 binding. {ECO:0000269|PubMed:15194795}.
    翻訳後: N-glycosylated. N-glycan at Asn-120: Hex5HexNAc4. {ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:22171320}.; Phosphorylated by Src kinases on tyrosine residues in the ITIM motif upon ligation. Interaction with TIGIT is required for Phosphorylation. {ECO:0000269|PubMed:15194502, ECO:0000269|PubMed:22421438}.
    疾患関連性: 0
    シーケンスの類似性: Belongs to the nectin family. {ECO:0000305}.; Contains 2 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.; Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhension, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.

    Immune Checkpoint
    Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
    Immune Checkpoint Proteins
    Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

    Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    CD155/PVR 代替名

    CD155/PVR 関連研究

  • Freistadt MS, et al. (2000) Hematopoietic cells from CD155-transgenic mice express CD155 and support poliovirus replication ex vivo. Microb Pathog. 29(4): 203-12.
  • Sato T, et al. (2004) Involvement of heterophilic trans-interaction of Necl-5/Tage4/PVR/CD155 with nectin-3 in formation of nectin- and cadherin-based adherens junctions. Genes Cells. 9(9): 791-9.
  • Kakunaga S, et al. (2004) Enhancement of serum- and platelet-derived growth factor-induced cell proliferation by Necl-5/Tage4/poliovirus receptor/CD155 through the Ras-Raf-MEK-ERK signaling. J Biol Chem. 279(35): 36419-25.
  • Sato T, et al. (2005) Common signaling pathway is used by the trans-interaction of Necl-5/Tage4/PVR/CD155 and nectin, and of nectin and nectin during the formation of cell-cell adhesion. Cancer Sci. 96(9): 578-89.
  • Minami Y, et al. (2007) Involvement of up-regulated Necl-5/Tage4/PVR/CD155 in the loss of contact inhibition in transformed NIH3T3 cells. Biochem Biophys Res Commun. 352(4): 856-60.
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