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マウス Interleukin-31 receptor A / IL31RA  遺伝子

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Interleukin-31 receptor A / IL31RA

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    Interleukin-31 receptor A / IL31RA サマリー & タンパク質情報

    Interleukin-31 receptor A / IL31RA 関連情報

    Interleukin-31 receptor A / IL31RA 背景

    サブユニット構造: Heterodimer with OSMR. Interacts with JAK1 and STAT3. {ECO:0000269|PubMed:15194700}.
    細胞内位置: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
    組織特異性: Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin. Detected in all of the myelomonocytic lineage. Expressed in CD14- and CD56-positive blood cells and by macrophages (at protein level). {ECO:0000269|PubMed:11877449, ECO:0000269|PubMed:14504285, ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:16461143}.
    誘導: Up-regulated in lesional keratinocytes of patients with atopic dermatitis. Up-regulated by IFNG/IFN-gamma and bacterial lipopolysaccharides (LPS). {ECO:0000269|PubMed:11877449, ECO:0000269|PubMed:14504285, ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:16461143}.
    翻訳後: N-glycosylated. {ECO:0000269|PubMed:14504285}.
    疾患関連性: DISEASE: Amyloidosis, primary localized cutaneous, 2 (PLCA2) [MIM:613955]: A primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. {ECO:0000269|PubMed:19690585}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    シーケンスの類似性: Belongs to the type I cytokine receptor family. Type 2 subfamily. {ECO:0000305}.; Contains 5 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.
    General information above from UniProt

    Interleukin-31 receptor A / IL31RA 代替名

    CRL,GPL,CRL3,GLMR,GLM-R,PLCA2,hGLM-R,IL-31RA,PRO21384, [homo-sapiens]
    UNQ6368/PRO21073/PRO21384,CRL,CRL3,GLM-R,GLMR,GPL,IL-31RA,PLCA2, PRO21384,hGLM-R, [Human]
    CRL3,GLM-R, GPL,Glmr,NR10, [mouse]
    GPL,CRL3,Glmr,NR10,GLM-R, [mus-musculus]

    Interleukin-31 receptor A / IL31RA 関連研究

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