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マウス IL22 / Interleukin 22  遺伝子

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IL22 / Interleukin 22

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    IL22 / Interleukin 22 サマリー & タンパク質情報

    IL22 / Interleukin 22 関連情報

    IL22 / Interleukin 22 背景

    細胞内位置: Secreted.
    シーケンスの類似性: Belongs to the IL-10 family. {ECO:0000305}.
    General information above from UniProt

    IL22 is a member of a group of cytokines called the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26),  a class of potent mediators of cellular inflammatory responses. It shares use of IL-10R2 in cell signaling with other members of this family, IL-10, IL-26, IL-28A/B and IL-29. IL22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL22 along with IL-17 is rapidly produced by splenic LTi-like cells and can be also produced by Th17 cells and likely plays a role in the coordinated response of both adaptive and innate immune systems.

    IL22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (sIL-22R1). IL22 and IL-10 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. IL22 can contribute to immune disease through the stimulation of inflammatory responses, S100s and defensins. IL22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. In some contexts, the pro-inflammatory versus tissue-protective functions of IL22 are regulated by the often co-expressed cytokine IL-17A.

    IL22 / Interleukin 22 代替名

    IL-21,TIFa,IL-22,ILTIF,IL-TIF,IL-D110,zcyto18,TIFIL-23, [homo-sapiens]
    interleukin 22,IL22,UNQ3099/PRO10096,IL-21,IL-22,IL-D110,IL-TIF,ILTIF,TIFIL-23,TIFa,zcyto18,IL-10-related T-cell-derived inducible factor,cytokine Zcyto18, [human]
    interleukin 22,Il22,mCG_123110,IL-22,IL-22a,ILTIFa,Iltif,IL-10-related T-cell-derived-inducible factor,IL-TIF alpha,ILTIF alpha,interleukin 10-related T cell-derived inducible factor,interleukin-22a, [mouse]
    IL-22,Iltif,IL-22a,ILTIFa, [mus-musculus]

    IL22 / Interleukin 22 関連研究

  • Pestka S. et al., 2004, Annu Rev Immunol. 22: 929-79.
  • Xie MH. et al., 2000, J Biol Chem. 275 (40): 31335-9.
  • Jones BC. et al., 2008, Structure. 16 (9): 1333-44.
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