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マウス IL20RA/IL-20RA  タンパク質

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IL20RA/IL-20RA

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    IL20RA/IL-20RA サマリー & タンパク質情報

    IL20RA/IL-20RA 関連情報

    IL20RA/IL-20RA 背景

    遺伝子の概要: The protein encoded by IL20RA gene is a receptor for interleukin 20 (IL20), a cytokine that may be involved in epidermal function. The receptor of IL20 is a heterodimeric receptor complex consisting of this protein and interleukin 20 receptor beta (IL20B). IL20RA gene and IL20B are highly expressed in skin. The expression of both genes is found to be upregulated in Psoriasis. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    サブユニット構造: Heterodimer with IL20RB and heterodimer with IL10RB.
    細胞内位置: Membrane; Single-pass type I membrane protein (By similarity).
    組織特異性: Widely expressed with highest levels in skin and testis and high levels in brain. Highly expressed in psoriatic skin.
    シーケンスの類似性: Belongs to the type II cytokine receptor family.
    Contains 2 fibronectin type-III domains.C
    General information above from UniProt

    Interleukin 20 receptor, alpha subunit (IL20RA/IL-20RA) also known as IL-20 receptor subunit alpha, Cytokine receptor class-II member 8, interleukin-20 receptor I, and interleukin-20 receptor subunit alpha, is a subunit for the interleukin-20 receptor. IL20RA/IL-20RA belongs to the type II cytokine receptor family. This cytokine is a receptor for interleukin 20 (IL20), a cytokine that may be involved in epidermal function. The receptor of IL20 is a heterodimeric receptor complex consisting of this protein and interleukin 20 receptor beta (IL20B). IL20RA forms heterodimer with IL20RB, and the complex serves as a receptor for IL19, IL20 and IL24. All three are capable of signaling through IL-20RA/IL-20RB complex. The ligand binding to receptor B creating a high-affinity binding site for the receptor A which is recruited to complete the complex. In addition, IL20RA also forms a heterodimer with the unique and specific receptor IL10RB and functions as the receptor for IL26. IL20RA is widely expressed with highest levels in skin, testis and brain. The expression of both IL20RA and IL20RB is found to be upregulated in psoriatic skin lesions on keratinocytes.

    IL20RA/IL-20RA 代替名

    CRF2-8,IL-20R1,IL-20RA,IL-20R-alpha, [homo-sapiens]
    FLJ40993,IL-20R1,IL20RA,RP11-204P2.1,ZCYTOR7, [human]
    E230031K19,Il20ra, [mouse]
    E230031K19, [mus-musculus]

    IL20RA/IL-20RA 関連研究

  • Parrish-Novak J, et al. (2002) Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. J Biol Chem. 277(49): 47517-23.
  • Kingo K, et al. (2008) Association analysis of IL20RA and IL20RB genes in psoriasis. Genes Immun. 9(5): 445-51.
  • Blumberg H, et al. (2001) Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell. 104(1): 9-19.
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