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マウス IL1RL1/IL‑1 R4  抗体

All IL1RL1 Reagents

IL1RL1/IL‑1 R4
反応度: Mouse  
アプリケーション: ELISA  WB  
51143-T48-50
51143-T48-200
51143-T48-100
50 µg 
200 µg 
100 µg 
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反応度: Mouse  
アプリケーション: ELISA  
51143-RP01-400
51143-RP01-200
51143-RP01-100
400 µg 
200 µg 
100 µg 
Add to Cart
    51143-M08HL-300 
    51143-M02HL-300 

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    IL1RL1/IL‑1 R4 サマリー & タンパク質情報

    IL1RL1/IL‑1 R4 関連情報

    IL1RL1/IL‑1 R4 背景

    遺伝子の概要: The protein encoded by IL1RL1 gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. IL1RL1 gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of IL1RL1 gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    サブユニット構造: Interacts with MYD88, IRAK1, IRAK4, and TRAF6. {ECO:0000269|PubMed:16286016, ECO:0000269|PubMed:23980170}.
    細胞内位置: Isoform C: Cell membrane.; Isoform B: Secreted.; Cell membrane {ECO:0000269|PubMed:11478810}; Single-pass type I membrane protein {ECO:0000269|PubMed:11478810}.
    組織特異性: Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. {ECO:0000269|PubMed:11478810}.
    シーケンスの類似性: Belongs to the interleukin-1 receptor family. {ECO:0000305}.; Contains 3 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.; Contains 1 TIR domain. {ECO:0000255|PROSITE-ProRule:PRU00204}.
    General information above from UniProt

    IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines.

    IL1RL1/IL‑1 R4 代替名

    IL1RL1/IL‑1 R4 関連研究

  • Savenije OE, et al. (2011) Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood. J Allergy Clin Immunol. 127(3): 750-6.
  • Li H, et al. (2000) The cloning and nucleotide sequence of human ST2L cDNA. Genomics. 67(3): 284-90.
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