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マウス IL18RAP  遺伝子

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IL18RAP
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IL18RAP サマリー & タンパク質情報

IL18RAP 関連情報

IL18RAP 背景

遺伝子の概要: The protein encoded by IL18RAP gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. [provided by RefSeq, Jul 2008]
General information above from NCBI
サブユニット構造: Together with IL18R1, probably belongs to the IL-18 receptor complex. Seems not to interact directly with IL-18. {ECO:0000269|PubMed:9792649}.
細胞内位置: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
組織特異性: Strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon, but not in any other tissue tested. Strongly expressed in T-cells polarized with IL-12. Specifically coexpressed with IL18R1 in Th1 cells. {ECO:0000269|PubMed:10925275, ECO:0000269|PubMed:11046021, ECO:0000269|PubMed:9792649}.
誘導: Induced by IFN-alpha and IL12/interleukin-12 in natural killer (NK) cells and T-cells. {ECO:0000269|PubMed:10925275}.
シーケンスの類似性: Belongs to the interleukin-1 receptor family. {ECO:0000305}.; Contains 2 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.; Contains 1 TIR domain. {ECO:0000255|PROSITE-ProRule:PRU00204}.
General information above from UniProt

Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. IL18RAP is required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex. IL18RAP together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Two putative isoforms of IL18RAP were detected and the ratios and total levels of these isoforms may contribute to the aetiology of coeliac disease. IL18R1 and IL18RAP polymorphisms have been found associated with diseases such as schizophrenia, HSV1 seropositivity and atopic asthma. Analysis of IL18R1 and IL18RAP SNPs in 5 European prospective cohorts suggests that the variability of these genes are unlikely to contribute to modulate the risk of CVD in European populations.

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IL18RAP 関連研究

  • Zhernakova A, et al.. (2008) Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. Am J Hum Genet. 82(5): 1202-10.
  • Grisoni ML, et al.. (2009) Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project. BMC Med Genet. 10: 44.
  • Koskinen LL, et al.. (2009) Association study of the IL18RAP locus in three European populations with coeliac disease. Hum Mol Genet. 18(6): 1148-55.
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