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マウス Dectin-1/CLEC7A  抗体

All CLEC7A Reagents

Dectin-1/CLEC7A
反応度: Mouse  
アプリケーション: FCM  
50233-R010-P-25
50233-R010-P-100
25 Test 
100 Tests 
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  • Slide 1
反応度: Mouse  
アプリケーション: ELISA  
50233-RP01-400
50233-RP01-200
50233-RP01-100
400 µg 
200 µg 
100 µg 
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    反応度: Mouse  
    アプリケーション: IF  ICC/IF  
    50233-R010-50
    50233-R010-100
    50 µg 
    100 µg 
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    • Slide 1
    反応度: Mouse  
    アプリケーション: ELISA  
    50233-R003-50
    50233-R003-100
    50 µg 
    100 µg 
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      反応度: Mouse  
      アプリケーション: ELISA  
      50233-RP02-50
      50233-RP02-200
      50233-RP02-100
      50 µg 
      200 µg 
      100 µg 
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        50233-M07HL-300 

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        Dectin-1/CLEC7A 関連経路

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          Dectin-1/CLEC7A サマリー & タンパク質情報

          Dectin-1/CLEC7A 背景

          遺伝子の概要: This CLEC7A gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Dectin-1 is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. Dectin-1 functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This CLEC7A gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
          General information above from NCBI
          サブユニット構造: Homodimer (By similarity). Interacts with SYK; participates in leukocyte activation in presence of fungal pathogens (By similarity). Isoform 5 interacts with RANBP9. {ECO:0000250, ECO:0000269|PubMed:16870151}.
          細胞内位置: Cell membrane {ECO:0000269|PubMed:11745369, ECO:0000269|PubMed:16870151, ECO:0000269|PubMed:17230442}; Single-pass type II membrane protein {ECO:0000269|PubMed:11745369, ECO:0000269|PubMed:16870151, ECO:0000269|PubMed:17230442}.; Isoform 5: Cytoplasm.; Isoform 6: Cytoplasm {ECO:0000305}.; Isoform 7: Cytoplasm {ECO:0000305}.
          組織特異性: Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta. {ECO:0000269|PubMed:11470510, ECO:0000269|PubMed:11491532, ECO:0000269|PubMed:11567029, ECO:0000269|PubMed:11745369, ECO:0000269|PubMed:12423684}.
          誘導: Up-regulated during differentiation from monocytes into dendritic cells. {ECO:0000269|PubMed:12423684}.
          翻訳後: Phosphorylated on tyrosine residues in response to glucan binding. {ECO:0000250}.
          疾患関連性: DISEASE: Candidiasis, familial, 4 (CANDF4) [MIM:613108]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269|PubMed:19864674}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
          シーケンスの類似性: Contains 1 C-type lectin domain. {ECO:0000255|PROSITE-ProRule:PRU00040}.
          General information above from UniProt

          Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection. In addition, dectin-1 is involved in the adaptive immune response as well as autoimmune diseases and immune tolerance. Dectin-1 can recognize and respond to live fungal pathogens and is being increasingly appreciated as having a key role in the innate responses to these pathogens. In addition to its exogenous ligands, Dectin-1 can recognize an unidentified endogenous ligand on T cells and may act as a co-stimulatory molecule. Recent studies have highlighted the importance of Dectin-1 in anti-fungal immunity, in both mice and humans, and have suggested a possible involvement of this receptor in the control of mycobacterial infections.

          Dectin-1/CLEC7A 代替名

          BGR,CANDF4,DECTIN1,CLECSF12, [homo-sapiens]
          beta-glucan receptor,BGR,CANDF4,CLEC7A,CLECSF12,Dectin-1,DECTIN1, [human]
          beta-glucan receptor,BGR,Clecsf12,Dectin-1,beta-GR,Clec7a, [mouse]
          BGR,beta-GR,Clecsf12, [mus-musculus]

          Dectin-1/CLEC7A 関連研究

        • Herre J, et al. (2004) The role of Dectin-1 in antifungal immunity. Crit Rev Immunol. 24(3): 193-203.
        • Brown GD. (2006) Dectin-1: a signalling non-TLR pattern-recognition receptor. 6(1): 33-43.
        • Sun L, et al. (2007) The biological role of dectin-1 in immune response. Int Rev Immunol. 26(5-6): 349-64.
        • Schorey JS, et al. (2008) The pattern recognition receptor Dectin-1: from fungi to mycobacteria. Curr Drug Targets. 9(2): 123-9.
        • Reid DM, et al. (2009) Pattern recognition: recent insights from Dectin-1. Curr Opin Immunol. 21(1): 30-7.
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