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マウス DEP1 / PTPRJ  抗体

All PTPRJ Reagents

DEP1 / PTPRJ
反応度: Mouse  
アプリケーション: 
102361-T08-50
102361-T08-200
102361-T08-100
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DEP1 / PTPRJ 関連製品

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DEP1 / PTPRJ サマリー & タンパク質情報

DEP1 / PTPRJ 背景

遺伝子の概要: The protein encoded by PTPRJ gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for PTPRJ gene. [provided by RefSeq, Jul 2008]
General information above from NCBI
触媒活性: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. {ECO:0000255|PROSITE-ProRule:PRU10044}.
サブユニット構造: Monomer. Interacts with CTNNB1 (phosphorylated) and JUP (phosphorylated). Interacts with FLT3 (phosphorylated). Interacts with GAB1 and GRB2. {ECO:0000269|PubMed:12370829, ECO:0000269|PubMed:12475979, ECO:0000269|PubMed:19246339, ECO:0000269|PubMed:21262971}.
細胞内位置: Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane {ECO:0000250}. Cell junction. Note=After T-cell stimulation, it is temporarily excluded from immunological synapses.
組織特異性: Expressed in the promyelocytic cell line HL-60, the granulocyte-macrophage colony-stimulating factor-dependent leukemic cell line F-36P, and the IL3 and erythropoietin-dependent leukemic cell line F-36E. Expressed predominantly in epithelial cells and lymphocytes. Enhanced expression at high cell density. {ECO:0000269|PubMed:12370829, ECO:0000269|PubMed:8483328, ECO:0000269|PubMed:9531590}.
翻訳後: N- and O-glycosylated. {ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:9531590}.
シーケンスの類似性: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. {ECO:0000305}.; Contains 9 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.; Contains 1 tyrosine-protein phosphatase domain. {ECO:0000255|PROSITE-ProRule:PRU00160}.
General information above from UniProt

DEP1 / PTPRJ (Receptor-type tyrosine-protein phosphatase eta) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. DEP1 / PTPRJ possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. DEP1 / PTPRJ is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. In stable MCF-7 cell lines lines, induction of DEP-1 expression inhibited breast cancer cell growth by 5-10-fold. These data describe PTPs expressed and regulated in breast cancer cell lines during differentiation and identify one PTP, DEP-1, that inhibits the growth of breast cancer cells in vitro.

DEP1 / PTPRJ 代替名

DEP1,SCC1,CD148,HPTPeta,R-PTP-ETA, [homo-sapiens]
CD148,CD148 antigen,density-enhanced phosphatase 1,DEP1,DEP-1,HPTP eta,HPTPeta,human density enhanced phosphatase-1,J polypeptide,protein tyrosine phosphatase,protein-tyrosine phosphatase eta,protein-tyrosine phosphatase receptor type J,receptor type,R-PTP-ETA,R-PTP-J,SCC1, [human]
density enhanced phosphatase-1,DEP-1,rCG_26744,receptor-type tyrosine-protein phosphatase eta, [mouse]
BET,Byp,Scc1,CD148,DEP-1,Ptpb2,RPTPJ,Scc-1,AI450271,PTPbeta2, [mus-musculus]

DEP1 / PTPRJ 関連研究

  • Holsinger LJ, et al. (2002) The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120. Oncogene. 21(46): 7067-76.
  • Huang X, et al. (2009) Natural variation at the DEP1 locus enhances grain yield in rice. Nat Genet. 41(4): 494-7.
  • Kuramochi S, et al. (1996) Molecular cloning and characterization of Byp, a murine receptor-type tyrosine phosphatase similar to human DEP-1. FEBS Lett. 378(1): 7-14.
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