Anti-NPC2 Magnetic Beads Immunoprecipitation (IP) Kit

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抗NPC2 磁気ビーズ免疫沈降(IP)キットの成分

Components Storage
Anti-NPC2 Magnetic Beads1,3 2-8℃ for 12 months
NP40 Cell Lysis Buffer2 -20℃ for 12 months
5×TBST(pH7.4)  
1×TBST(pH7.4)  
ddH2O  
Alkaline Elution Buffer 2-8℃ for 12 months
Acidity Elution Buffer 2-8℃ for 12 months
Neutralization Buffer 2-8℃ for 12 months

【1】The IP KIT contains anti-NPC2 magnetic Beads (2 mg/mL) in phosphate buffered saline (PBS, pH 7.4) with sodium azide (0.1%).

【2】Using NP-40 cell lysate buffer in the kit is required,otherwise,the magnetic beads may be precipitated.

【3】Shipping: Magnetic Beads kits are shipped at ambient temperature in which magnetic beads are provided in liquid buffer.

抗NPC2 磁気ビーズ免疫沈降(IP)キットの製品説明

The Anti-NPC2 magnetic Beads, conjugated with Anti-NPC2 antibody, are used for immuneprecipitation (IP) of NPC2 proteins which expressed in vitro expression systems. For IP, the beads are added to a sample containing NPC2 proteins to form a bead-protein complex. The complex is removed from the solution manually using a magnetic separator. The bound NPC2 proteins are dissociated from the magnetic beads using an elution buffer.

抗NPC2 磁気ビーズ免疫沈降(IP)キット抗体の情報

抗体
Recombinant Anti-NPC2 Antibody, Rabbit Monoclonal(13341-R012)
免疫原
Recombinant Human NPC2 Protein (Catalog#13341-H08H)
交差反応
Human NPC2
ソース
Monoclonal Human Rabbit IgG
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Human NPC2 (rh NPC2; Catalog#13341-H08H; NP_006423.1; Met1-Leu151).
アプリケーション
Immunoprecipitation (IP), Minimum Protein Purification

Anti-NPC2 Magnetic Beads Immunoprecipitation (IP) Kit: 別名

Anti-EDDM1ALCAM Magnetic Beads-Immunoprecipitatiopn (IP) Kit; Anti-HE1ALCAM Magnetic Beads-Immunoprecipitatiopn (IP) Kit

NPC2 背景情報

Niemann-Pick Type C2 (NPC2) plays an important role in the regulation of intracellular cholesterol homeostasis via direct binding with free cholesterol. NPC2 is an intralysosomal protein that binds cholesterol in vitro. NPC2 is a small lysosomal glycoprotein that binds cholesterol with submicromolar affinity. Deficiency in NPC2 is the cause of Niemann-Pick type C2 disease, a fatal neurovisceral disorder characterized by the accumulation of cholesterol in lysosomes. Niemann-Pick disease, type C2 (NPC2) protein is one of the most abundant components of the epididymal fluid and contains a functional cholesterol-binding site that can transfer cholesterol between membranes, it has been suggested for years that NPC2 could be involved in the regulation of cholesterol levels in spermatozoa during epididymal maturation.
完全な名称
Niemann-Pick disease, type C2
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