Anti-CD46 Magnetic Beads Immunoprecipitation (IP) Kit

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抗CD46 磁気ビーズ免疫沈降(IP)キットの成分

Components Storage
Anti-CD46 Magnetic Beads1,3 2-8℃ for 12 months
NP40 Cell Lysis Buffer2 -20℃ for 12 months
5×TBST(pH7.4)  
1×TBST(pH7.4)  
ddH2O  
Alkaline Elution Buffer 2-8℃ for 12 months
Acidity Elution Buffer 2-8℃ for 12 months
Neutralization Buffer 2-8℃ for 12 months

【1】The IP KIT contains anti-CD46 magnetic Beads (2 mg/mL) in phosphate buffered saline (PBS, pH 7.4) with sodium azide (0.1%).

【2】Using NP-40 cell lysate buffer in the kit is required,otherwise,the magnetic beads may be precipitated.

【3】Shipping: Magnetic Beads kits are shipped at ambient temperature in which magnetic beads are provided in liquid buffer.

抗CD46 磁気ビーズ免疫沈降(IP)キットの製品説明

The Anti-CD46 magnetic Beads, conjugated with Anti-CD46 antibody, are used for immuneprecipitation (IP) of CD46 proteins which expressed in vitro expression systems. For IP, the beads are added to a sample containing CD46 proteins to form a bead-protein complex. The complex is removed from the solution manually using a magnetic separator. The bound CD46 proteins are dissociated from the magnetic beads using an elution buffer.

抗CD46 磁気ビーズ免疫沈降(IP)キット抗体の情報

抗体
Anti-CD46 Antibody, Rabbit Polyclonal(12239-RP02)
免疫原
Recombinant Human CD46 protein (Catalog#12239-H08H)
交差反応
Human CD46
ソース
Polyclonal Human Rabbit IgG
調製
Produced in rabbits immunized with purified, recombinant Human CD46 (rh CD46; Catalog#12239-H08H; EAW93471.1; Met 1-Asp 328). CD46 specific IgG was purified by Human CD46 affinity chromatography.
アプリケーション
Immunoprecipitation (IP), Minimum Protein Purification

Anti-CD46 Magnetic Beads Immunoprecipitation (IP) Kit: 別名

Anti-AHUS2ALCAM Magnetic Beads-Immunoprecipitatiopn (IP) Kit; Anti-MCPALCAM Magnetic Beads-Immunoprecipitatiopn (IP) Kit; Anti-MIC10ALCAM Magnetic Beads-Immunoprecipitatiopn (IP) Kit; Anti-TLXALCAM Magnetic Beads-Immunoprecipitatiopn (IP) Kit; Anti-TRA2.10ALCAM Magnetic Beads-Immunoprecipitatiopn (IP) Kit

CD46 背景情報

CD46, also known as Membrane Cofactor Protein (MCP), is a complement regulatory protein. CD46 is a type 1 membrane protein that plays an important inhibitory role in the complement system. CD46 is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. Human CD46 shares 5% amino acid sequence identity with mouse and rat CD46. The importance of CD46 to complement regulation is underscored by the observation that genetic loss of CD46 leads to development of atypical hemolytic-uremic syndrome (aHUS), a disease characterized by uncontrolled complement activation. CD46 is implicated in the development and/or progression of selected cancer types.
完全な名称
CD46 molecule, complement regulatory protein
Related Pathways
  • Complement Activation Pathways
    Complement Activation Pathways
参考文献
  • Lublin D.M., et al.,(1988), Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins. J. Exp. Med. 168:181-194.
  • Purcell D.F., et al., (1991), Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation.Immunogenetics 33:335-344.
  • Post T.W., et al.,(1991), Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype.J. Exp. Med. 174:93-102.
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