Interleukin-10 Receptor

Interleukin-10 (IL-10) regulates growth and differentiation of B cells, NK cells, cytotoxic and helper T cells, mast cells, granulocytes, dendritic cells and endothelial cells. All the biological activities of Interleukin-10 (IL-10) are realized by cell membrane receptors binding to IL-10. Interleukin-10 (IL-10) plays a key role in differentiation and function of a newly appreciated type of T cell, the T regulatory cell, which may figure prominently in control of immune responses and tolerance in vivo. Uniquely among hemopoietic cytokines, Interleukin-10 (IL-10) has closely related homologs in several virus genomes, which testify to its crucial role in regulating immune and inflammatory responses.

The IL-10 receptor (IL-10R) is composed of two subunits (IL10RA and IL10RB) that are members of the interferon receptor (IFNR) family. IL-10RA is the ligand-binding subunit with high affinity, and its molecular size is 90–120 kDa. IL-10RB is utilized as accessory subunit for IL-10R signaling. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. Interleukin-10 receptor IL-10RA, is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.

Interleukin-10 Receptor Related Diseases

Inflammatory bowel disease (IBD) encompasses a heterogeneous group of diseases that are characterized by chronic intestinal inflammation with a complex etiology. These lymphomas had some of the characteristics of diffuse large B-cell lymphomas and contained monoclonal, Epstein-Barr virus–negative germinal center B cells. The tumors displayed a remarkably homogeneous signature, with original activation of the nuclear factor κB pathway and a decrease in intratumor T-cell infiltration. Recent work has demonstrated that IBD with an early-onset within the first months of life can be monogenic: mutations in Interleukin-10 (IL-10) or interleukin-10 receptor (IL-10 receptor) lead to a loss of IL-10 function and cause severe intractable enterocolitis in infants and small children.

Anti Interleukin-10 Receptor / Anti IL-10 Receptor Antibody

Inflammatory bowel disease (IBD) encompasses a heterogeneous group of diseases that are characterized by chronic intestinal inflammation with a complex etiology. These lymphomas had some of the characteristics of diffuse large B-cell lymphomas and contained monoclonal, Epstein-Barr virus–negative germinal center B cells. The tumors displayed a remarkably homogeneous signature, with original activation of the nuclear factor κB pathway and a decrease in intratumor T-cell infiltration. Recent work has demonstrated that IBD with an early-onset within the first months of life can be monogenic: mutations in Interleukin-10 (IL-10) or interleukin-10 receptor (IL-10 receptor) lead to a loss of IL-10 function and cause severe intractable enterocolitis in infants and small children.

Receptors
Receptors Classification
Cytokine Receptors+
- Chemokine Receptor
- IFN Receptor
- TNF Receptor
- CSF Receptor
- Interleukin Receptor
Interleukin-1 Receptor
Interleukin-6 Receptor
Interleukin-10 Receptor
Interleukin-12 Receptor
Interleukin-17 Receptor
- TGF-beta Superfamily Receptors
Receptors by Differentiation Cells
Receptors by Functions
Receptors Reagent Products
Receptors by Species