ICAM4: ICAM4 Protein | ICAM4 Antibody

ICAM4 Gene family

ICAM4 Background

ICAM4, also known as CD242, is a member of the?immunoglobulin superfamily, ICAM family. ICAM4 contains 2?Ig-like C2-type (immunoglobulin-like) domains. It is similar to the intercellular adhesion molecule (ICAM) protein family. ICAM4 binds to the leukocyte adhesion LFA-1 protein. ICAM4's first reported receptors were CD11a/CD18 and CD11b/CD18. ICAM4 functions as a ligand for the monocyte/macrophage-specific CD11c/CD18. Deletion of the individual immunoglobulin domains of ICAM4 demonstrated that both its domains contain binding sites for CD11c/CD18. CD11c/CD18 is expressed on macrophages in spleen and bone marrow. Inhibition of erythrophagocytosis by anti-ICAM4 and anti-integrin antibodies suggests a role for these interactions in removal of senescent red cells.

Reference for ICAM4

  • Gorst DW. et al., 1980, Vox Sanguinis. 38 (2): 99-105.
  • Vos GH. et al., 1973, Blood. 42 (3): 445-53.
  • Kim W. et al., 2011, Mol Cell. 44 (2): 325-40.
  • Daniels G. et al., 2002, Transfusion Medicine. 12 (5): 287-95.

ICAM4 Protein

ICAM4 protein function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins. {ECO:0000269|PubMed:11435317}.

ICAM4 protein expression

Tissue specificity

Erythrocytes.

ICAM4 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    271.00
  • Mass (Da)
    29.00

ICAM4 Gene

ICAM4 gene / cDNA is a protein-coding gene which located on 19p13.2. The ICAM4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.119 organisms have orthologs with human gene ICAM4.