ICOS ligand cDNA ORF Clone, Human, untagged

1/1
Price:
Size:
Number:

ICOS ligand cDNA ORF Clone, Human, untagged: 製品情報

遺伝子
Human
NCBI 参考シーケンス番号
遺伝子の長さ
908 bp
シーケンスの特徴
Identical with the Gene Bank Ref. ID sequence.
製品の特徴
Full length Clone DNA of Human inducible T-cell co-stimulator ligand.
プラスミド
プロモーター
Enhanced CMV promoter
ベクター
制限部位
HindIII + XbaI (6.1kb + 0.91kb)
シークエンシングプライマー
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
品質管理
The plasmid is confirmed by full-length sequencing.
スクリーニング
細菌スクリーニング抵抗力
Ampicillin
細胞スクリーニング抵抗力
Hygromycin
アプリケーション
Stable or Transient mammalian expression
保存 & 配送
配送方法
Each tube contains lyophilized plasmid.
保存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

ICOS ligand cDNA ORF ヌクレオチド配列およびアミノ酸配列に関する情報

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

ICOS ligand cDNA ORF Clone, Human, untagged: 検証済の画像

ICOS ligand cDNA ORF Clone, Human, untagged: 別名

B7-h2 cDNA ORF Clone, Human; B7H2 cDNA ORF Clone, Human; B7RP-1 cDNA ORF Clone, Human; B7RP1 cDNA ORF Clone, Human; CD275 cDNA ORF Clone, Human; GL50 cDNA ORF Clone, Human; ICOS ligand cDNA ORF Clone, Human; ICOS-L cDNA ORF Clone, Human; ICOSL cDNA ORF Clone, Human; ICOSLG cDNA ORF Clone, Human; LICOS cDNA ORF Clone, Human

ICOS ligand 背景情報

Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.
完全な名称
inducible T-cell co-stimulator ligand
参考文献
  • Flesch IE. (2002) Inducible costimulator-ligand (ICOS-L). J Biol Regul Homeost Agents. 16(3): 217-9.
  • Kajiwara K, et al. (2009) Expression and function of the inducible costimulator ligand B7-H2 in human airway smooth muscle cells. Allergol Int. 58(4): 573-83.
  • Wong SC, et al. (2009) Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity. Cell Immunol. 256(1-2): 64-71.

ICOS ligand cDNA ORFクローン, Rat, 関連製品

ICOS ligand cDNA ORFクローン, Cynomolgus, 関連製品

カートに追加しました カートに追加しませんでした カートを更新しています。少々お待ちください