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ITGB1 / Integrin beta-1 / CD29

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ITGB1 / Integrin beta-1 / CD29 サマリー & タンパク質情報

ITGB1 / Integrin beta-1 / CD29 背景

サブユニット構造: Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Interacts with seprase FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner. Binds LGALS3BP and NMRK2, when associated with alpha-7, but not with alpha-5. Interacts with FGR and HCK. Interacts (via the cytoplasmic region) with RAB25 (via the hypervariable C-terminal region). Interacts with RAB21. Interacts with KRT1 in the presence of GNB2L1 and SRC. Interacts with AMICA1; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling AMICA1 homodimerization. Interacts with HIV-1 Tat. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts with FLNA, FLNB and RANBP9. Isoform 5 interacts with ACE2. Isoform 1 interacts with the C-terminal region of FLNC. Interacts with MYO10. Interacts with DAB2. Interacts with FERMT2; the interaction is inhibited in presence of ITGB1BP1. Interacts with ITGB1BP1 (via C-terminal region); the interaction is a prerequisite for focal adhesion disassembly. Interacts with TLN1; the interaction is prevented by competitive binding of ITGB1BP1. Interacts with human cytomegalovirus/HHV-5 envelope glycoprotein B/gB. Interacts with ACAP1; required for ITGB1 recycling. Interacts with ASAP3. Isoform 5 interacts with alpha-7A and alpha-7B in adult skeletal muscle. Isoform 5 interacts with alpha-7B in cardiomyocytes of adult heart. Interacts with EMP2; the interaction may be direct or indirect and ITGB1 has an heterodimer form (By similarity). {ECO:0000250|UniProtKB:P09055, ECO:0000269|PubMed:10397733, ECO:0000269|PubMed:10455171, ECO:0000269|PubMed:10613898, ECO:0000269|PubMed:11741838, ECO:0000269|PubMed:11807098, ECO:0000269|PubMed:11807099, ECO:0000269|PubMed:12473654, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15156152, ECO:0000269|PubMed:15181153, ECO:0000269|PubMed:15276642, ECO:0000269|PubMed:16076904, ECO:0000269|PubMed:16256741, ECO:0000269|PubMed:16754960, ECO:0000269|PubMed:17925226, ECO:0000269|PubMed:17956333, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:20660204, ECO:0000269|PubMed:21325030, ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:22027826, ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:22645133, ECO:0000269|PubMed:23317506, ECO:0000269|PubMed:8411387, ECO:0000269|PubMed:9501082}.
細胞内位置: Cell membrane {ECO:0000303|PubMed:10455171}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, invadopodium membrane {ECO:0000269|PubMed:10455171}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, ruffle membrane {ECO:0000303|PubMed:10455171}; Single-pass type I membrane protein {ECO:0000255}. Recycling endosome. Melanosome. Cleavage furrow. Cell projection, lamellipodium. Cell projection, ruffle. Note=Isoform 2 does not localize to focal adhesions. Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells. In a lung cancer cell line, in prometaphase and metaphase, localizes diffusely at the membrane and in a few intracellular vesicles. In early telophase, detected mainly on the matrix-facing side of the cells. By mid-telophase, concentrated to the ingressing cleavage furrow, mainly to the basal side of the furrow. In late telophase, concentrated to the extending protrusions formed at the opposite ends of the spreading daughter cells, in vesicles at the base of the lamellipodia formed by the separating daughter cells. Colocalizes with ITGB1BP1 and metastatic suppressor protein NME2 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen. Translocates from peripheral focal adhesions sites to fibrillar adhesions in a ITGB1BP1-dependent manner. Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner. {ECO:0000269|PubMed:10455171, ECO:0000303|PubMed:10455171}.; Isoform 5: Cell membrane, sarcolemma {ECO:0000250}. Cell junction {ECO:0000250}. Note=In cardiac muscle, isoform 5 is found in costameres and intercalated disks. {ECO:0000250}.
組織特異性: Isoform 1 is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform 2 is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform 3 and isoform 4 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform 4, rather than isoform 3, is selectively expressed in peripheral T-cells. Isoform 3 is expressed in non-proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform 5 is expressed specifically in striated muscle (skeletal and cardiac muscle). {ECO:0000269|PubMed:1551917, ECO:0000269|PubMed:2249781, ECO:0000269|PubMed:7544298, ECO:0000269|PubMed:7545396, ECO:0000269|PubMed:7681433, ECO:0000269|PubMed:9494094}.
翻訳後: The cysteine residues are involved in intrachain disulfide bonds. {ECO:0000250}.
シーケンスの類似性: Belongs to the integrin beta chain family. {ECO:0000305}.; Contains 1 VWFA domain. {ECO:0000305}.
General information above from UniProt

ITGB1 / Integrin beta-1 / CD29 代替名

CD29,FNRB,MDF2,VLAB,GPIIA,MSK12,VLA-BETA, [homo-sapiens]
CD29,Fnrb,gpIIa,Gm9863,AA409975,AA960159,4633401G24Rik,ENSMUSG00000051907, [mus-musculus]

ITGB1 / Integrin beta-1 / CD29 関連研究