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人々 DCIR/CLEC4A/CLECSF6  抗体

All DCIR Reagents

DCIR/CLEC4A/CLECSF6
反応度: Human  
アプリケーション: 
11476-MM04-50
11476-MM04-200
11476-MM04-100
11476-MM04-1
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200 µg 
100 µg 
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    反応度: Human  
    アプリケーション: IHC-P  
    11476-MM06-50
    11476-MM06-200
    11476-MM06-100
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    • Slide 1
    • Slide 1
    反応度: Human  
    アプリケーション: ELISA  
    11476-RP02-50
    11476-RP02-200
    11476-RP02-100
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      反応度: Human  
      アプリケーション: ELISA  
      11476-R007-50
      11476-R007-100
      50 µg 
      100 µg 
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        反応度: Human  
        アプリケーション: ELISA  
        11476-RP01-400
        11476-RP01-200
        11476-RP01-100
        400 µg 
        200 µg 
        100 µg 
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          反応度: Human  
          アプリケーション: ELISA  FCM  
          11476-MM08-50
          11476-MM08-200
          11476-MM08-100
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          200 µg 
          100 µg 
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          • Slide 1
          反応度: Human  
          アプリケーション: FCM  
          11476-MM08-P-25
          11476-MM08-P-100
          25 Test 
          100 Tests 
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          • Slide 1
          反応度: Human  
          アプリケーション: FCM  
          11476-MM08-F-25
          11476-MM08-F-100
          25 Test 
          100 Tests 
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          • Slide 1
          反応度: Human  
          アプリケーション: ELISA  
          11476-MM02-50
          11476-MM02-200
          11476-MM02-100
          11476-MM02-1
          50 µg 
          200 µg 
          100 µg 
          1 mg 
          Add to Cart
            11476-H07HL-300 

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              DCIR/CLEC4A/CLECSF6 関連製品

              DCIR/CLEC4A/CLECSF6 関連製品

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              DCIR/CLEC4A/CLECSF6 サマリー & タンパク質情報

              DCIR/CLEC4A/CLECSF6 背景

              遺伝子の概要: This CLEC4A gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this CLEC4A gene. This CLEC4A gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
              General information above from NCBI
              サブユニット構造: May interact with PTPN6 via its ITIM motif.
              ドメイン: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
              細胞内位置: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
              組織特異性: Expressed in dendritic cells, myeloid cells, B-cells and HL-60 cells (at protein level). TNF alpha, IL-1 alpha, and LPS, down-regulated expression at the surface of neutrophils (at protein level). Expressed preferentially in hematopoietic tissues. Expressed in peripheral blood leukocytes, neutrophils, moderate quantities in spleen, lymph node, and bone marrow, and at very low levels in thymus. Expressed in Ag-presenting cells (DC, monocytes, macrophages and B-cells), as well as on granulocytes. Expression was decreased in DC by signals inducing its maturation (e.g. CD40 ligand, LPS, and TNF alpha). {ECO:0000269|PubMed:10438934, ECO:0000269|PubMed:11178971, ECO:0000269|PubMed:11994513}.
              誘導: Isoform 2 mRNA expression is up-regulated by agonists of neutrophils CSF2/GM-CSF, IL3/interleukin-3, IL4/interleukin-4 and IL13/interleukin-13. {ECO:0000269|PubMed:11994513}.
              シーケンスの類似性: Contains 1 C-type lectin domain. {ECO:0000255|PROSITE-ProRule:PRU00040}.
              General information above from UniProt

              Dendritic cell immunoreceptor (DCIR), also known as C-type lectin domain family 4 member A (CLEC4A), C-type lectin superfamily member 6 (CLECSF6), is a single-pass type II C-type lectin receptor expressed mainly in dendritic cells (DCs), which is a negative regulator of DC expansion and has a crucial role in maintaining the homeostasis of the immune system. The Dectin-2 family of C-type lectins that includes Dectin-2, BDCA-2, DCIR, DCAR, Clecsf8 and Mincle. These type II receptors contain a single extracellular carbohydrate recognition domain and have diverse functions in both immunity and homeostasis. DCIR is the only member of the family which contains a cytoplasmic signalling motif and has been shown to act as an inhibitory receptor, while BDCA-2, Dectin-2, DCAR and Mincle all associate with FcRgamma chain to induce cellular activation, including phagocytosis and cytokine production. Dectin-2 and Mincle have been shown to act as pattern recognition receptors for fungi, while DCIR acts as an attachment factor for HIV. In addition to pathogen recognition, DCIR has been shown to be pivotal in preventing autoimmune disease by controlling dendritic cell proliferation. DCIR expressed on antigen presenting cells and granulocytes and acts as an inhibitory receptor via an intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM). It may also be involved via its ITIM motif in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. Additionally, DCIR can participate in the capture of HIV-1 and promote infection in trans and in cis of autologous CD4(+) T cells from human immature monocyte-derived DCs. DCIR acts as a ligand for HIV-1 and is involved in events leading to productive virus infection.

              DCIR/CLEC4A/CLECSF6 代替名

              DCIR,CLEC4A,CLECSF6,DDB27,HDCGC13P,LLIR, [human]
              Clec4a,Clecsf6,DCIR,Dcir1, [mouse]

              DCIR/CLEC4A/CLECSF6 関連研究

            • Kanazawa N, et al. (2004) Signaling and immune regulatory role of the dendritic cell immunoreceptor (DCIR) family lectins: DCIR, DCAR, dectin-2 and BDCA-2. Immunobiology. 209(1-2): 179-90.
            • Fujikado N, et al. (2008) Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells. Nat Med. 14(2): 176-80.
            • Lambert AA, et al. (2008) The C-type lectin surface receptor DCIR acts as a new attachment factor for HIV-1 in dendritic cells and contributes to trans- and cis-infection pathways. Blood. 112(4): 1299-307.
            • Graham LM, et al. (2009) The Dectin-2 family of C-type lectins in immunity and homeostasis. Cytokine. 48(1-2): 148-55.
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