4-1BBL Protein, Human, Recombinant (ECD, Fc Tag)

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4-1BBL Protein, Human, Recombinant (ECD, Fc Tag): 製品情報

純度
> 85 % as determined by SDS-PAGE.
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
活性
1.Measured by its binding ability in a functional ELISA.
2.Immobilized human TNFRSF9 (Cat:10041-H08H) at 10μg/mL (100μL/well) can bind human TNFSF9 (Cat:15693-H01H),the EC50 of human TNFSF9 is 7-40ng/mL.
タンパク質の構築
A DNA sequence encoding the human TNFSF9 (NP_003802.1) (Arg71-Glu254) was expressed with the Fc region of human IgG1 at the N-terminus.
NP No.
発現ホスト
HEK293 Cells
Human
予測N末端
Glu
分子量
The recombinant human TNFSF9 consists 444 amino acids and predicts a molecular mass of 47.9 kDa.
バッファー
Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
配送
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
安定性 & 保存条件
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
再構成
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

4-1BBL Protein, Human, Recombinant (ECD, Fc Tag): 画像

4-1BBL Protein, Human, Recombinant (ECD, Fc Tag): 別名

4-1BB-L Protein, Human; 4-1BBL Protein, Human; CD137L Protein, Human

4-1BBL 背景情報

4-1BBL is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as dendritic cells, macrophages, and activated B cells. Members of the TNF-TNF receptor superfamily have been shown to play critical roles in regulating cellular activation, differentiation and apoptosis. Several studies have reported that 4-1BBL/4-1BB interaction provided a co-stimulatory signal to T cells, and increased T cell proliferation and cytokines production. In additon, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.
完全な名称
tumor necrosis factor (ligand) superfamily, member 9
参考文献
  • Cheung CT, (2007) Neutralizing anti-4-1BBL treatment improves cardiac function in viral myocarditis. Lab Invest. 87(7): 651-61.
  • Wang C, et al. (2009) Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol Rev. 229(1): 192-215.
  • Habib-Agahi M, et al. (2009) 4-1BBL costimulation retrieves CD28 expression in activated T cells. Cell Immunol. 256(1-2): 39-46.
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