Anti-c-MET Antibody (FITC)

1/1
Price:
Size:
Number:

Anti-c-MET Antibody (FITC) (Rabbit Monoclonal 抗体) の製品情報

製品名
Anti-c-MET Antibody (FITC)
検証済のアプリケーション
FCM
交差反応
Reacts with: Human
特異性
Human c-MET
免疫原
Recombinant Human HGFR / c-MET protein (Catalog#10692-H08H)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Human HGFR / c-MET (rh HGFR / c-MET; Catalog#10692-H08H; NP_000236; Met 1-Thr 932) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
ソース
Monoclonal Rabbit IgG Clone #271
精製
Protein A
緩衝液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
標識物
FITC
濃度
10 μl/Test, 0.1 mg/ml
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-c-MET Antibody (FITC) (Rabbit Monoclonal 抗体) の画像

Profile of anti-human C-Met (HGF R) reactivity on HepG2 cells analyzed by flow cytometry. The Clone R271 and R243 (Cat. No. 10692-R243-F) monoclonal antibodies are not cross-blocking.

Anti-c-MET Antibody (FITC): 別名

Anti-AUTS9 Antibody; Anti-c-Met Antibody; Anti-DFNB97 Antibody; Anti-HGFR Antibody; Anti-RCCP2 Antibody

c-MET 背景情報

Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that has been shown to be overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.
完全な名称
MET proto-oncogene, receptor tyrosine kinase
参考文献
  • McGill GG, et al. (2006) c-Met expression is regulated by Mitf in the melanocyte lineage. J Biol Chem. 281(15): 10365-73.
  • Garcia S, et al. (2007) c-Met overexpression in inflammatory breast carcinomas: automated quantification on tissue microarrays. British journal of cancer. 96(2): 329-35.
  • Socoteanu MP, et al. (2008) c-Met targeted therapy of cholangiocarcinoma. World J Gastroenterol. 14(19): 2990-4.
  • Kong DS, et al. (2009) Prognostic significance of c-Met expression in glioblastomas. Cancer. 115(1): 140-8.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

カートに追加しました カートに追加しませんでした カートを更新しています。少々お待ちください