Drug targets for Cancer: COX2

Drug Targets for Cancer: COX2 and Cancer

High expression levels of cyclooxygenase 2 expression and infiltration by regulatory T cells (Tregs) are often associated with tumor progression. In human breast cancer patients, the percentage of Tregs at the tumor site is positively correlated with disease progression to normal tissue to ductal carcinoma in situ (DCIS), and from DCIS to invasive carcinoma. Despite the correlation between Treg accumulation and worsened disease outcome, the mechanisms by which Tregs promote tumor progression remain unclear. Of note, the levels of cyclooxygenase 2 (COX2) and of its main product prostaglandin E2 (PGE2) have also been associated to poor outcome in many tumor models and clinical studies. Although reports have correlated the upregulation of COX2 with increased levels of Tregs in breast cancer, no mechanistic data on this observation was available.

Drug Targets for Cancer: COX2 related Products

Drug targets for cancer: COX2 research reagents

Other vital drug targets for cancer likeCOX2:

Drug Targets for Cancer: COX2 Related Reference

Karavitis J, Zhang M. COX2 regulation of breast cancer bone metastasis. Oncoimmunology. 2013;2(3):e23129. doi:10.4161/onci.23129.

Drug Targets for Cancer: COX2 Related Information

Drug Targets for Cancer