Anti-DDR1 Antibody

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Anti-DDR1 Antibody (Rabbit Polyclonal 抗体) の製品情報

製品名
Anti-DDR1 Antibody
検証済のアプリケーション
WB,IHC-P
交差反応
Reacts with: Rat
特異性
Rat DDR1
免疫原
Recombinant Rat DDR1/MCK10/CD167 Protein (Catalog#80440-R08H)
調製
Produced in rabbits immunized with purified, recombinant Rat DDR1/MCK10/CD167 (rR DDR1/MCK10/CD167; Catalog#80440-R08H; Q6MG19; Met1-Thr413). DDR1/MCK10/CD167 specific IgG was purified by Rat DDR1/MCK10/CD167 affinity chromatography.
ソース
Polyclonal Rabbit IgG
精製
Protein A & Antigen Affinity
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-DDR1 Antibody (Rabbit Polyclonal 抗体) 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
WB 1:500-1:2000
IHC-P 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-DDR1 Antibody (Rabbit Polyclonal 抗体) の画像

Anti-DDR1 rabbit polyclonal antibody at 1:500 dilution

Lane A: SKBR3 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti- Rabbit  IgG H&L (Dylight 800)  at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:101 kDa

Observed band size:93 kDa

Immunochemical staining of rat DDR1 in rat kidney with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).

Anti-DDR1 Antibody: 別名

Anti-Cak Antibody; Anti-Drd1 Antibody; Anti-PTK3D Antibody

DDR1 背景情報

Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 1 (MCK1), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK1/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK1/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway.
完全な名称
discoidin domain receptor tyrosine kinase 1
参考文献
  • Hou G, et al. (2001) The discoidin domain receptor tyrosine kinase DDR1 in arterial wound repair. J Clin Invest. 107(6): 727-35.
  • Ongusaha PP, et al. (2003) p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop. EMBO J. 22(6): 1289-301.
  • Jönsson M, et al. (2001) Repression of Wnt-5a impairs DDR1 phosphorylation and modifies adhesion and migration of mammary cells. J Cell Sci. 114(11): 2043-53.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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