Anti-DDR1 Antibody (APC)

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Anti-DDR1 Antibody (APC) (Mouse Monoclonal 抗体) の製品情報

製品名
Anti-DDR1 Antibody (APC)
検証済のアプリケーション
FCM
交差反応
Reacts with: Human
特異性
Human DDR1
免疫原
Recombinant Human DDR1 Kinase / MCK10 / CD167 Protein (Catalog#10730-H08H)
調製
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human DDR1 Kinase / MCK10 / CD167 (rh DDR1 Kinase / MCK10 / CD167; Catalog#10730-H08H; NP_001945.3; Met1-Thr416) and conjugated with APC under optimum conditions, the unreacted APC was removed.
ソース
Monoclonal Mouse IgG1 Clone #05
精製
Protein A
緩衝液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
標識物
APC
濃度
5 μl/Test, 0.1 mg/ml
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-DDR1 Antibody (APC) (Mouse Monoclonal 抗体) の画像

Flow cytometric analysis of Human DDR1(CD167a) expression on MCF-7 cells. Cells were stained with APC-conjugated anti-Human DDR1(CD167a). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Anti-DDR1 Antibody (APC): 別名

Anti-CAK Antibody; Anti-CD167 Antibody; Anti-DDR Antibody; Anti-EDDR1 Antibody; Anti-HGK2 Antibody; Anti-MCK10 Antibody; Anti-NEP Antibody; Anti-NTRK4 Antibody; Anti-PTK3 Antibody; Anti-PTK3A Antibody; Anti-RTK6 Antibody; Anti-TRKE Antibody

DDR1 背景情報

Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 1 (MCK1), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK1/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK1/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway.
完全な名称
discoidin domain receptor tyrosine kinase 1
参考文献
  • Hou G, et al. (2001) The discoidin domain receptor tyrosine kinase DDR1 in arterial wound repair. J Clin Invest. 107(6): 727-35.
  • Ongusaha PP, et al. (2003) p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop. EMBO J. 22(6): 1289-301.
  • Jönsson M, et al. (2001) Repression of Wnt-5a impairs DDR1 phosphorylation and modifies adhesion and migration of mammary cells. J Cell Sci. 114(11): 2043-53.

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