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IGFBP7 抗体, ウサギモノクローナル抗体

データシートレビュープロトコル
製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
13100-H07H-50
13100-H07H-20
50 µg 
20 µg 
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製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
13100-H08H-50
13100-H08H-20
50 µg 
20 µg 
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製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
13100-H02H-50
13100-H02H-5
13100-H02H-20
50 µg 
5 µg 
20 µg 
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発現宿主: Human Cells  
  • Slide 1
51125-M02H-20
51125-M02H-100
20 µg 
100 µg 
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IGFBP7 antibody 背景

Insulin like growth factor binding protein 7 (IGFBP7) is a member of the IGFBP family. It has been identified in colorectal adenocarcinoma (CRC) cell lines. The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1. IGFBPs are clearly distinct but are sharing regions with strong homology. All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity. Insulin-like growth factor (IGF) binding proteins (IGFBPs) have been shown to either inhibit or enhance the action of IGF, or act in an IGF-independent manner in the prostate. IGFBP7 could inhibit cell growth, decrease soft agar colony formation activity and induce apoptosis in RKO and SW620 cells. There is mounting evidence that the structure of the IGFBP proteins plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence and IGF affinity.

人々 IGFBP7 antibody 参考文献
  • Oh Y, et al. (1996) Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II. J Biol Chem. 271(48): 30322-5.
  • Wilson EM, et al. (1997) Generation and characterization of an IGFBP-7 antibody: identification of 31kD IGFBP-7 in human biological fluids and Hs578T human breast cancer conditioned media. J Clin Endocrinol Metab. 82(4): 1301-3.
  • Lin J, et al. (2007) Methylation patterns of IGFBP7 in colon cancer cell lines are associated with levels of gene expression. J Pathol. 212(1): 83-90.
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