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IL6ST / gp130 / CD130 抗体, ウサギポリクローナル抗体, Antigen Affinity Purified

データシートレビュープロトコル
発現宿主: Human Cells  
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10974-H02H-50
10974-H02H-10
50 µg 
10 µg 
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発現宿主: Human Cells  
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10974-HCCH-200
10974-HCCH-100
200 µg 
100 µg 
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製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
10974-H03H-20
10974-H03H-10
20 µg 
10 µg 
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製品の説明: Active  
発現宿主: CHO Cells  
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50135-M03C-200
50135-M03C-100
200 µg 
100 µg 
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製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
50135-M08H-200
50135-M08H-100
200 µg 
100 µg 
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製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
50135-M03H-200
50135-M03H-100
200 µg 
100 µg 
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製品の説明: Active  
発現宿主: Human Cells  
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80030-R06H-50
80030-R06H-100
50 µg 
100 µg 
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製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
80030-R08H-50
80030-R08H-100
50 µg 
100 µg 
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発現宿主: Human Cells  
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90275-C02H-200
90275-C02H-100
200 µg 
100 µg 
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発現宿主: Human Cells  
  • Slide 1
90275-C08H-200
90275-C08H-100
200 µg 
100 µg 
Add to Cart

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IL6ST/gp130/CD130 antibody 背景

Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.

ラット IL6ST/gp130/CD130 antibody 参考文献
  • Hibi, et al. (1990) Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell. 63 (6): 1149-57.
  • Kim H, et al. (1997) Transmembrane domain of gp130 contributes to intracellular signal transduction in hepatic cells. J Biol Chem. 272 (49): 30741-7.
  • Giordano V, et al. (1997) Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase. J Immunol. 158 (9): 4097-103.
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