Cluster of differentiation in T Lymphocyte

T cells have important roles in immune responses and function by directly secreting soluble mediators or through cell contact-dependent mechanisms. T cells can be separated into three major groups based on function: cytotoxic T cells, helper T cells (Th), and regulatory T cells (Tregs). Many T cell subsets have been characterized. Differential expression of antigens on the cell surface, as well as their distinct cytokine secretion profiles, provide valuable clues to the diverse nature and function of T cells. Further knowledge of how these T cell subsets are regulated and cooperate with each other will provide us with better tools to treat immune-related diseases.

For example, CD8+ cytotoxic T cells destroy infected target cells through the release of perforin, granzymes, and granulysin, whereas CD4+ T helper cells (ie, Th1, Th2, Th9, Th17, and Tfh cells) have little cytotoxic activity and secrete cytokines that act on other leucocytes such as B cells, macrophages, eosinophils, or neutrophils to clear pathogens. Tregs suppress T-cell function by several mechanisms including binding to effector T-cell subsets and preventing secretion of their cytokines.

CD antigens / Cluster of differentiation
CD antigens
CD antigens reagent products
Non-CD cellular antigens
Clusters of differentiation
what is cluster of differentiation
cluster of differentiation nomenclature
cluster of differentiation as markers
cluster of differentiation function
cluster of differentiation classification by Immunophenotyping+
- cluster of differentiation in stem cells
- cluster of differentiation in granulocyte
- cluster of differentiation in monocyte
- cluster of differentiation in T lymphocyte
- cluster of differentiation in helper T cell
- cluster of differentiation in regulatory T cell
- cluster of differentiation in cytotoxic T cell
- cluster of differentiation in B lymphocyte
- cluster of differentiation in platelet
- cluster of differentiation in NK cell
cluster of differentiation 4 / CD4
cluster of differentiation 8 / CD8
cluster of differentiation 3 / CD3
clusters of differentiation of the B7 family
clusters of differentiation of FC receptor
human Leukocyte Differentiation Antigen workshop