Cluster of differentiation in monocyte

Monocytes are known to originate in the bone marrow from a common myeloid progenitor. Monocytes express various receptors, which monitor and sense environmental changes. Monocytes are highly plastic and heterogeneous, and change their functional phenotype in response to environmental stimulation. Evidence from murine and human studies has suggested that monocytosis can be an indicator of various inflammatory diseases. Monocytes can differentiate into inflammatory or anti-inflammatory subsets. Upon tissue damage or infection, monocytes are rapidly recruited to the tissue, where they can differentiate into tissue macrophages or dendritic cells.

Monocytes were initially identified by their expression of large amounts of CD14. However, the subsequent identification of differential expression of antigenic markers showed that monocytes in human peripheral blood are hetero geneous. CD16 is expressed on the surface of monocytes. Differential expression of CD14 and CD16 allowed monocytes to be divided into two subsets: CD14hiCD16cells, which are often called classic monocytes, because this phenotype resembles the original description of monocytes; and CD14+CD16+ cells. Mouse blood monocytes are identified primarily by their expression of CD115, CD11b, and the F4/80 antigen. For example, human monocytes have also been classified based on their CD64 expression , as well as on expression of the adhesion molecule CD56. Additionally, CD68 is a very classic marker for human macrophages. Some people use CD71 to distinguish between monocytes and macrophages, because it is abundant in macrophages but minimally expressed in monocytes.

CD antigens / Cluster of differentiation
CD antigens
CD antigens reagent products
Non-CD cellular antigens
Clusters of differentiation
what is cluster of differentiation
cluster of differentiation nomenclature
cluster of differentiation as markers
cluster of differentiation function
cluster of differentiation classification by Immunophenotyping+
- cluster of differentiation in stem cells
- cluster of differentiation in granulocyte
- cluster of differentiation in monocyte
- cluster of differentiation in T lymphocyte
- cluster of differentiation in helper T cell
- cluster of differentiation in regulatory T cell
- cluster of differentiation in cytotoxic T cell
- cluster of differentiation in B lymphocyte
- cluster of differentiation in platelet
- cluster of differentiation in NK cell
cluster of differentiation 4 / CD4
cluster of differentiation 8 / CD8
cluster of differentiation 3 / CD3
clusters of differentiation of the B7 family
clusters of differentiation of FC receptor
human Leukocyte Differentiation Antigen workshop