Cluster of differentiation 3γ/ CD3γ

CD3D is also known as CD3-DELTA, T3D, and is a single-pass type I membrane protein. CD3D is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. Defects in CD3D cause severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T-/B+/NK+ SCID) which is a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels.

Human CD3d / CD3δ Antibody by IHC Application

Caption: Immunochemical staining of human CD3D in human spleen with mouse Mab (15 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to membrane of T cells.

Human CD3d / CD3δ Antibody by WB Application

CD antigens / Cluster of differentiation
CD antigens
CD antigens reagent products
Non-CD cellular antigens
Clusters of differentiation
what is cluster of differentiation
cluster of differentiation nomenclature
cluster of differentiation as markers
cluster of differentiation function
cluster of differentiation classification by Immunophenotyping
cluster of differentiation 4 / CD4
cluster of differentiation 8 / CD8
cluster of differentiation 3 / CD3+
- cluster of differentiation 3γ
- cluster of differentiation 3δ
- cluster of differentiation 3ε
clusters of differentiation of the B7 family
clusters of differentiation of FC receptor
human Leukocyte Differentiation Antigen workshop