Chemokine Receptor

Chemokine receptors are 7-transmembrane G-protein-coupled receptors, and include 18 members. Chemokine receptors express on different cell types and their binding and response to specific chemokines are highly variable. According to their binding to four distinct subfamilies of chemokines, chemokine receptors can be divided into four different families, CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors and XC chemokine receptors. Four families of chemokine receptors differ in spacing of cysteine residues near N-terminal of the receptor.

Chemokine receptors are members of cytokine receptors and have also recently been implicated in human cancers including those of the breast, lung, prostate, colon, and melanoma. Chemokine receptors may potentially facilitate tumor dissemination at several key steps of metastasis, including adherence of tumor cells to endothelium, extravasation from blood vessels, metastatic colonization, angiogenesis, proliferation, and protection from the host response via activation of key survival pathways such as phosphatidylinositol-3 kinase and Akt.

Moreover, most fascinating has been the observation that chemokine receptors act as co-receptor in HIV type 1 infection. With the help of chemokine receptor CCR5 or CXCR4, HIV-1 binds CD4 and penetrates its nucleic acid into the host cell.

CC and XC Chemokine Receptor Molecules List

Chemokine Receptors Ligands
CCR1 CCL3, CCL4, CCL5, CCL7, CCL14, CCL15, CCL16, CCL23
CCR2 CCL2, CCL7, CCL8, CCL12, CCL13
CCR3 CCL5, CCL7, CCL11, CCL13, CCL15, CCL24, CCL26, CCL28
CCR4 CCL2, CCL3, CCL5, CCL17, CCL22
CCR5 CCL3, CCL4, CCL5, CCL8
CCR6 CCL20
CCR7 CCL19, CCL21
CCR8 CCL1, CCL4, CCL17
CCR9 CCL25
CCR10 CCL27, CCL28
CCL27, CCL28 XCL1, XCL2

CXC and CX3C Chemokine Receptor Molecules List

Chemokine Receptors Ligands
CX3CR1 CX3CL1
CXCR1 CXCL6, CXCL8
CXCR2 CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, CXCL8
CXCR3 CXCL9, CXCL10, CXCL11
CXCR4 CXCL12
CXCR5 CXCL13
CXCR6 CXCL16
Receptors
Receptors Classification
What are Receptors
Cytokine Receptors+
- Chemokine Receptor
- IFN Receptor
- TNF Receptor
- CSF Receptor
- Interleukin Receptor
- TGF-beta Superfamily Receptors
Growth Factor Receptors
Fc Receptor / FcR
Receptors by Differentiation Cells
Receptors by Functions
Receptors Reagent Products
Receptors by Species