LFA-1 cDNA ORF Clone, Rat, C-GFPSpark® tag

LFA-1 cDNA ORF Clone, Rat, C-GFPSpark® tag: 製品情報

遺伝子
Rat
NCBI 参考シーケンス番号
遺伝子の長さ
3483 bp
製品の特徴
Full length Clone DNA of Rat integrin, alpha L with C terminal GFPSpark tag.
プラスミド
プロモーター
Enhanced CMV promoter
ベクター
タグシーケンス
GFPSpark: GTGAGCAAGGGC……GAGCTGTACAAG
シークエンシングプライマー
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
品質管理
The plasmid is confirmed by full-length sequencing.
スクリーニング
細菌スクリーニング抵抗力
Kanamycin
細胞スクリーニング抵抗力
Hygromycin
アプリケーション
Stable or Transient mammalian expression
保存 & 配送
配送方法
Each tube contains lyophilized plasmid.
保存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

LFA-1 背景情報

ITGAL (Integrin Subunit Alpha L) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. ITGAL encodes the integrin alpha L chain, which belongs to the integrin alpha chain family. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. Hypomethylation of regions flanking the ITGAL promoter may increase CD11a expression and suggest that age-dependent hypomethylation of promoters lacking CpG islands, perhaps due to decreased DNA methyltransferase expression, may be one mechanism contributing to increased T cell gene expression with aging. Diseases associated with ITGAL include Immune-Complex Glomerulonephritis and Chronic Venous Insufficiency.
完全な名称
integrin subunit alpha L
Related Pathways
  • Actin Dynamics Signaling Pathway
    Actin Dynamics Signaling Pathway
  • AKT Signaling Pathway
    AKT Signaling Pathway
  • G Protein-coupled Receptors Signaling
    G Protein-coupled Receptors Signaling
  • MAPK-Erk Pathway
    MAPK-Erk Pathway
  • Autophagy Pathway
    Autophagy Pathway
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