Caspase-7 Lentiviral cDNA ORF Clone, Rat, C-GFPSpark® tag

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Caspase-7 Lentiviral cDNA ORF Clone, Rat, C-GFPSpark® tag: 製品情報

遺伝子
Rat
NCBI 参考シーケンス番号
遺伝子の長さ
912 bp
シーケンスの特徴
Identical with the Gene Bank Ref. ID sequence (Nucleotide may contain silent mutation without changing amino acid sequence)
製品の特徴
Full length Clone DNA of Rattus norvegicus caspase 7
プラスミド
プロモーター
Enhanced CMV mammalian cell promoter
ベクター
タグシーケンス
GFPSpark Tag Sequence: GTGAGCAAGGGC……GAGCTGTACAAG
シークエンシングプライマー
pLen-F(CTCGTTTAGTGAACCGTCAGAATT), pLen-R(GAACCGGAACCCTTAAACATGT)
品質管理
The plasmid is confirmed by full-length sequencing.
スクリーニング
細菌スクリーニング抵抗力
Ampicillin
保存 & 配送
配送方法
Each tube contains 10μg lyophilized plasmid
保存条件
The lyophilized plasmid can be stored at room temperature for three months

Caspase-7に関するより多くの情報

Entrez Gene ID

Caspase-7 背景情報

Caspase 7, also known as caspase-7 and MCH3, belongs to the cysteine-aspartic acid protease (caspase) family. Caspases play a role in the signal transduction pathways of apoptosis, necrosis and inflammation. There are two major classes of caspases: initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-1,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the executioner caspases. Caspase 7 exists in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. Caspase 7 cannot be detected in the brain. Caspase 7 functions in the activation cascade of caspases responsible for apoptosis execution. It cleaves and activates sterol regulatory element binding proteins (SREBPs). It proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Overexpression promotes programmed cell death.
完全な名称
caspase 7, apoptosis-related cysteine peptidase
Related Pathways
  • Death Receptor Signaling
    Death Receptor Signaling
  • EGFR Signaling Pathway
    EGFR Signaling Pathway
  • p53 Pathway
    p53 Pathway
  • TNF Signaling
    TNF Signaling
  • IL17 signaling pathway
    IL17 signaling pathway
参考文献
  • Riedl S J, et al. (2001) Structural basis for the inhibition of caspase-3 by XIAP. Cell. 104(5):791-800.
  • Roy N, et al. (1997) The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. 16(23):6914-25.
  • Deveraux Q L, et al. (1997) X-linked IAP is a direct inhibitor of cell-death proteases. Nature. 388(6639): 300-4.
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