UBXN4 cDNA ORF Clone in Cloning Vector, Mouse

UBXN4 cDNA ORF Clone in Cloning Vector, Mouse: 製品情報

NCBI 参考シーケンス番号
1521 bp
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 485C>T(T162I).
Full length Clone DNA of Mouse UBX domain protein 4.
M13-47 and RV-M
The plasmid is confirmed by full-length sequencing.
保存 & 配送
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.

UBXN4 cDNA ORF ヌクレオチド配列およびアミノ酸配列に関する情報

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

UBXN4 cDNA ORF Clone in Cloning Vector, Mouse: 別名

1300013G12Rik cDNA ORF Clone, Mouse; mKIAA0242 cDNA ORF Clone, Mouse; Ubxd2 cDNA ORF Clone, Mouse

UBXN4 背景情報

UBXN4 (UBX Domain Protein 4) is a Protein Coding gene. The UBXN4 gene, located on 2q21.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, and frog. UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP) and promotes ER-associated protein degradation (ERAD). UBXD2 acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD. UBXN4 is widely expressed in the thyroid, gall bladder, and other tissues. Diseases associated with UBXN4 include Martsolf Syndrome. An important paralog of this gene is TNRC6A. 238 organisms have orthologs with the human gene UBXN4.
UBX domain protein 4
  • Mueller B, et al. (2008) Sel1l nucleates a protein complex required for dislocation of misfolded glycoproteins. Proc Natl Acad Sci U S A 105 (34): 12325-12330.
  • Madsen L, et al. (2014) Human aspl/tug interacts with p97 and complements the proteasome mislocalization of a yeast ubx4 mutant, but not the er-associated degradation defect. BMC Cell Biol 15 31.
  • Li X, et al. (2012) A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal transplantation in developed countries. Hum Mol Genet 21 (2): 421-429.

UBXN4 cDNA ORFクローン, Rat, 関連製品

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