TST cDNA ORF Clone, Mouse, N-Myc tag

TST cDNA ORF Clone, Mouse, N-Myc tag: 製品情報

遺伝子
Mouse
NCBI 参考シーケンス番号
遺伝子の長さ
894 bp
製品の特徴
Full length Clone DNA of Mouse thiosulfate sulfurtransferase, mitochondrial with N terminal Myc tag.
プラスミド
プロモーター
Enhanced CMV promoter
ベクター
タグシーケンス
Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
シークエンシングプライマー
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
品質管理
The plasmid is confirmed by full-length sequencing.
スクリーニング
細菌スクリーニング抵抗力
Kanamycin
細胞スクリーニング抵抗力
Hygromycin
アプリケーション
Stable or Transient mammalian expression
保存 & 配送
配送方法
Each tube contains lyophilized plasmid.
保存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

TST cDNA ORF Clone, Mouse, N-Myc tag: 別名

Rhodanese cDNA ORF Clone, Mouse

TST 背景情報

Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, is a mitochondrial enzyme that catalyzes the transfer of sulfur in several molecular pathways. The TST gene, located on 22q12.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, C.elegans, and frog. This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. Also, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. TST is widely expressed in the colon, liver, and other tissues. TST deficiency was shown to be strongly related to the pathophysiology of metabolic diseases including diabetes and obesity.
完全な名称
thiosulfate sulfurtransferase (rhodanese)
参考文献
  • Włodek P, et al. (2010) Thiol levels, protein carbonylation and anaerobic sulfur metabolism in erythrocytes of peritoneal dialysis and predialysis patients. Nephrology (Carlton) 15 (8): 755-761.
  • Libiad M, et al. (2015) Polymorphic variants of human rhodanese exhibit differences in thermal stability and sulfur transfer kinetics. J Biol Chem 290 (39): 23579-23588.
  • Kruithof PD, et al. (2020) Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases. Biochim Biophys Acta Mol Basis Dis 1866 (6): 165716.

TST cDNA ORFクローン, Human, 関連製品

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