SLC1A5 cDNA ORF Clone, Mouse, N-His tag

SLC1A5 cDNA ORF Clone, Mouse, N-His tag: 製品情報

遺伝子
Mouse
NCBI 参考シーケンス番号
遺伝子の長さ
1668 bp
製品の特徴
Full length Clone DNA of Mouse solute carrier family 1 (neutral amino acid transporter), member 5 with N terminal His tag.
プラスミド
プロモーター
Enhanced CMV promoter
ベクター
タグシーケンス
His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
シークエンシングプライマー
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
品質管理
The plasmid is confirmed by full-length sequencing.
スクリーニング
細菌スクリーニング抵抗力
Kanamycin
細胞スクリーニング抵抗力
Hygromycin
アプリケーション
Stable or Transient mammalian expression
保存 & 配送
配送方法
Each tube contains lyophilized plasmid.
保存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

SLC1A5 cDNA ORF Clone, Mouse, N-His tag: 別名

AAAT cDNA ORF Clone, Mouse; ASCT2 cDNA ORF Clone, Mouse; ATBO cDNA ORF Clone, Mouse; M7V1 cDNA ORF Clone, Mouse; M7VS1 cDNA ORF Clone, Mouse; R16 cDNA ORF Clone, Mouse; RDRC cDNA ORF Clone, Mouse; Slc1a7 cDNA ORF Clone, Mouse

SLC1A5 背景情報

SLC1A5 (solute carrier family 1, member 5), known as ASCT2, is a small neutral amino acid exchanger that is upregulated in rapidly proliferating lymphocytes but also many primary human cancers. SLC1A5 is a neutral amino acid transporter belonging to the SLC1 family and localized in the plasma membrane of several body districts. Solute-linked carrier family A1 member 5 (SLC1A5), which has a high affinity to neutral amino acids, is essential for glutamine transport and amino acid metabolism in various cancers. One of SLC1A5's primary substrates is the immunomodulatory amino acid glutamine, which plays an important role in multiple key processes, such as energy supply, macromolecular synthesis, nucleotide biosynthesis, redox homeostasis, and resistance against oxidative stress. These processes are also essential to immune cells, including neutrophils, macrophages, B, and T lymphocytes.
完全な名称
solute carrier family 1 (neutral amino acid transporter), member 5
参考文献
  • Scalise M, et al. (2019) Interaction of cholesterol with the human slc1a5 (asct2): Insights into structure/function relationships. Front Mol Biosci 6 110.
  • Scalise M, et al. (2018) The human slc1a5 (asct2) amino acid transporter: From function to structure and role in cell biology. Front Cell Dev Biol 6 96.
  • Masle-Farquhar E, et al. (2017) Asct2 (slc1a5)-deficient mice have normal b-cell development, proliferation, and antibody production. Front Immunol 8 549.
  • Lin J, et al. (2018) Slc1a5 silencing inhibits esophageal cancer growth via cell cycle arrest and apoptosis. Cell Physiol Biochem 48 (1): 397.
カートに追加しました カートに追加しませんでした カートを更新しています。少々お待ちください U.S.A.