RBM7 (RNA Binding Motif Protein 7) is a Protein Coding gene. The RBM7 gene, located on 11q23.1-q23.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. RBM7 is an RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is a ternary complex composed of the RNA-binding protein RBM7, the scaffold zinc-knuckle protein ZCCHC8, and the helicase MTR4. RBM7 is widely expressed in bone marrow, urinary bladder, and other tissues. 191 organisms have orthologs with the human gene RBM7.
RNA binding motif protein 7
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Hrossova D, et al. (2015) Rbm7 subunit of the next complex binds u-rich sequences and targets 3'-end extended forms of snrnas. Nucleic Acids Res 43 (8): 4236-4248.