The Mtfr1 has been confirmed as a targeted gene of miR-324-5p through miRTarBase software and western blot. miR-324-5p protects against oxidative stress-induced EPCs injury by regulating Mtfr1. Knocking down Mtfr1 suppresses mitochondrial fission, apoptosis, and myocardial infarction. Mtfr1 is a direct target of miR-324-5p, and miR-324-5p attenuates mitochondrial fission, cardiomyocyte apoptosis, and myocardial infarction by suppressing Mtfr1 translation. Mtfr1 (mitochondrial fission regulator 1), is a gene involved in the regulation of antioxidant activity in the mouse testis. Mtfr1 protects the male gonads against oxidative stress. Mtfr1/Chppr is a nuclear gene coding for a mitochondrial protein capable of inducing fission of this organelle in a sequence-specific manner.
mitochondrial fission regulator 1
Wang K, et al. (2015) Nfat4-dependent mir-324-5p regulates mitochondrial morphology and cardiomyocyte cell death by targeting mtfr1. Cell Death Dis 6 (12): e2007.
Monticone M, et al. (2007) Impaired expression of genes coding for reactive oxygen species scavenging enzymes in testes of mtfr1/chppr-deficient mice. Reproduction 134 (3): 483-492.
Chen P, et al. (2019) Mir-324-5p protects against oxidative stress-induced endothelial progenitor cell injury by targeting mtfr1. J Cell Physiol 234 (12): 22082-22092.