MTFR1 cDNA ORF Clone in Cloning Vector, Mouse

MTFR1 cDNA ORF Clone in Cloning Vector, Mouse: 製品情報

NCBI 参考シーケンス番号
987 bp
Identical with the Gene Bank Ref. ID sequence.
Full length Clone DNA of Mouse mitochondrial fission regulator 1.
SP6 and T7 or M13-47 and RV-M
The plasmid is confirmed by full-length sequencing.
保存 & 配送
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.

MTFR1 cDNA ORF ヌクレオチド配列およびアミノ酸配列に関する情報

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

MTFR1 cDNA ORF Clone in Cloning Vector, Mouse: 別名

1300002C08Rik cDNA ORF Clone, Mouse; 1700080D04Rik cDNA ORF Clone, Mouse; 2810026O10Rik cDNA ORF Clone, Mouse; 4930579E05Rik cDNA ORF Clone, Mouse; Chppr cDNA ORF Clone, Mouse; Fam54a2 cDNA ORF Clone, Mouse

MTFR1 背景情報

The Mtfr1 has been confirmed as a targeted gene of miR-324-5p through miRTarBase software and western blot. miR-324-5p protects against oxidative stress-induced EPCs injury by regulating Mtfr1. Knocking down Mtfr1 suppresses mitochondrial fission, apoptosis, and myocardial infarction. Mtfr1 is a direct target of miR-324-5p, and miR-324-5p attenuates mitochondrial fission, cardiomyocyte apoptosis, and myocardial infarction by suppressing Mtfr1 translation. Mtfr1 (mitochondrial fission regulator 1), is a gene involved in the regulation of antioxidant activity in the mouse testis. Mtfr1 protects the male gonads against oxidative stress. Mtfr1/Chppr is a nuclear gene coding for a mitochondrial protein capable of inducing fission of this organelle in a sequence-specific manner.
mitochondrial fission regulator 1
  • Wang K, et al. (2015) Nfat4-dependent mir-324-5p regulates mitochondrial morphology and cardiomyocyte cell death by targeting mtfr1. Cell Death Dis 6 (12): e2007.
  • Monticone M, et al. (2007) Impaired expression of genes coding for reactive oxygen species scavenging enzymes in testes of mtfr1/chppr-deficient mice. Reproduction 134 (3): 483-492.
  • Chen P, et al. (2019) Mir-324-5p protects against oxidative stress-induced endothelial progenitor cell injury by targeting mtfr1. J Cell Physiol 234 (12): 22082-22092.
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