MMP7 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag

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MMP7 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag: 製品情報

遺伝子
Mouse
NCBI 参考シーケンス番号
遺伝子の長さ
804 bp
シーケンスの特徴
Identical with the Gene Bank Ref. ID sequence (Nucleotide may contain silent mutation without changing amino acid sequence)
製品の特徴
Full length Clone DNA of Mus musculus matrix metallopeptidase 7.
プラスミド
プロモーター
Enhanced CMV mammalian cell promoter
ベクター
タグシーケンス
GFPSpark Tag Sequence: GTGAGCAAGGGC……GAGCTGTACAAG
シークエンシングプライマー
pLen-F(CTCGTTTAGTGAACCGTCAGAATT), pLen-R(GAACCGGAACCCTTAAACATGT)
品質管理
The plasmid is confirmed by full-length sequencing.
スクリーニング
細菌スクリーニング抵抗力
Ampicillin
保存 & 配送
配送方法
Each tube contains 10μg lyophilized plasmid
保存条件
The lyophilized plasmid can be stored at room temperature for three months

MMP7 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag: 別名

MAT cDNA ORF Clone, Mouse

MMP7 背景情報

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological and pathological processes such as morphogenesis, differentiation, angiogenesis, tissue remodeling, and tumor invasion. MMPs are synthesized as pro-enzymes and converted to active form by extracellular proteinases. MMP7, also referred to as matrilysin, is the smallest member of the MMP family and differs from other MMP members in that it lacks the C-terminal hemopexin-like domain. MMP7 is produced primarily by mucosal epithelia, and is capable of degrading various ECM proteins including proteoglycans, fibronectin, elastin and casein. This enzyme serves essential functions in both innate defense and wound healing, and appears to be one of the most important MMPs in human colon cancers. It has been reported that MMP7 contributes to tumor malignancy probably by cleaving cell surface proteins such as Fas ligand, degradation of IgG or inducing E-cadherin-mediated cell aggregation. In addition, matrilysin is also identified as a mediator of pulmonary fibrosis and a potential therapeutic target.
完全な名称
matrix metallopeptidase 7
研究分野
参考文献
  • Muller D., et al.,(1988), The collagenase gene family in humans consists of at least four members. Biochem. J. 253:187-192.
  • Marti H.P., et al., (1992), Molecular characterization of a low-molecular-mass matrix metalloproteinase secreted by glomerular mesangial cells as PUMP-1.Biochem. J. 285:899-905.
  • Gaire M., et al.,(1994), Structure and expression of the human gene for the matrix metalloproteinase matrilysin.J. Biol. Chem. 269:2032-2040.
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