PSMD7 (Proteasome 26S Subunit, Non-ATPase 7) is a Protein Coding gene. The PSMD7 gene, located on 16q23.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat, etc. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17. PSMD7, a 19S proteasome subunit, is overexpressed in most carcinoma cells. It forms a dimer with PSMD14 that functions in the removal of the attached ubiquitin chain. PSMD7 is widely expressed in bone marrow, placenta, and other tissues. Diseases associated with PSMD7 include Huntington's Disease and Tracheitis. PSMD7 and the mTOR/p70S6K pathway may be a promising candidate for developing therapies for esophageal squamous cell carcinoma (ESCC).
proteasome 26S subunit, non-ATPase 7
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