PSMD7 cDNA ORF Clone, Human, N-Myc tag

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PSMD7 cDNA ORF Clone, Human, N-Myc tag: 製品情報

遺伝子
Human
NCBI 参考シーケンス番号
遺伝子の長さ
975 bp
製品の特徴
Full length Clone DNA of Human proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 with N terminal Myc tag.
プラスミド
プロモーター
Enhanced CMV promoter
ベクター
タグシーケンス
Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
シークエンシングプライマー
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
品質管理
The plasmid is confirmed by full-length sequencing.
スクリーニング
細菌スクリーニング抵抗力
Kanamycin
細胞スクリーニング抵抗力
Hygromycin
アプリケーション
Stable or Transient mammalian expression
保存 & 配送
配送方法
Each tube contains lyophilized plasmid.
保存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

PSMD7 cDNA ORF Clone, Human, N-Myc tag: 別名

MOV34 cDNA ORF Clone, Human; P40 cDNA ORF Clone, Human; Rpn8 cDNA ORF Clone, Human; S12 cDNA ORF Clone, Human

PSMD7 背景情報

PSMD7 (Proteasome 26S Subunit, Non-ATPase 7) is a Protein Coding gene. The PSMD7 gene, located on 16q23.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat, etc. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17. PSMD7, a 19S proteasome subunit, is overexpressed in most carcinoma cells. It forms a dimer with PSMD14 that functions in the removal of the attached ubiquitin chain. PSMD7 is widely expressed in bone marrow, placenta, and other tissues. Diseases associated with PSMD7 include Huntington's Disease and Tracheitis. PSMD7 and the mTOR/p70S6K pathway may be a promising candidate for developing therapies for esophageal squamous cell carcinoma (ESCC).
完全な名称
proteasome 26S subunit, non-ATPase 7
参考文献
  • Shi K, et al. (2018) Psmd7 downregulation induces apoptosis and suppresses tumorigenesis of esophageal squamous cell carcinoma via the mtor/p70s6k pathway. FEBS Open Bio 8 (4): 533-543.
  • Niu Z, et al. (2011) A polymorphism rs17336700 in the psmd7 gene is associated with ankylosing spondylitis in chinese subjects. Ann Rheum Dis 70 (4): 706-707.
  • Alves BS, et al. (2006) Characterization of the human ortholog of mov34 reveals eight n-terminal residues important for mpn domain stability. Biochem Biophys Res Commun 347 (3): 608-615.
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