PDLIM1 cDNA ORF Clone, Human, N-DYKDDDDK (Flag®) tag

PDLIM1 (PDZ And LIM Domain 1) is a Protein Coding gene. The PDLIM1 gene, located on 10q23.33, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. This gene encodes a member of the enigma protein family. The protein contains two protein-interacting domains, a PDZ domain at the amino-terminal end and one to three LIM domains at the carboxyl-terminal. PDLIM1 is widely expressed in the small intestine, colon, and other tissues, and the protein may function as an adapter to bring other LIM-interacting proteins to the cytoskeleton. Pseudogenes associated with this gene are located on chromosomes 3, 14, and 17. Diseases associated with PDLIM1 include Supravalvular Aortic Stenosis and Donohue Syndrome.

PDZ and LIM domain 1

• Miehe U, et al. (2006) Expression of the actin stress fiber-associated protein clp36 in the human placenta. Histochem Cell Biol 126 (4): 465-471.
• Liu Z, et al. (2015) Pdz and lim domain protein 1(pdlim1)/clp36 promotes breast cancer cell migration, invasion and metastasis through interaction with α-actinin. Oncogene 34 (10): 1300-1311.
• Kotaka M, et al. (1999) Characterization of the human 36-kda carboxyl terminal lim domain protein (hclim1). J Cell Biochem 72 (2): 279-285.