PDLIM1 (PDZ And LIM Domain 1) is a Protein Coding gene. The PDLIM1 gene, located on 10q23.33, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. This gene encodes a member of the enigma protein family. The protein contains two protein-interacting domains, a PDZ domain at the amino-terminal end and one to three LIM domains at the carboxyl-terminal. PDLIM1 is widely expressed in the small intestine, colon, and other tissues, and the protein may function as an adapter to bring other LIM-interacting proteins to the cytoskeleton. Pseudogenes associated with this gene are located on chromosomes 3, 14, and 17. Diseases associated with PDLIM1 include Supravalvular Aortic Stenosis and Donohue Syndrome.
PDZ and LIM domain 1
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