P38 Gamma/MAPK12 cDNA ORF Clone, Human, untagged

P38 Gamma/MAPK12 cDNA ORF Clone, Human, untagged: 製品情報

遺伝子
Human
NCBI 参考シーケンス番号
遺伝子の長さ
1074 bp
シーケンスの特徴
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 183T/C,603T/C not causing the amino acid variation.
製品の特徴
Full length Clone DNA of Human mitogen-activated protein kinase 12
プラスミド
プロモーター
Enhanced CMV mammalian cell promoter
ベクター
制限部位
HindIII + NotI(6.1kb+1.07kb)
シークエンシングプライマー
T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
品質管理
The plasmid is confirmed by full-length sequencing.
スクリーニング
細菌スクリーニング抵抗力
Ampicillin
細胞スクリーニング抵抗力
Hygromycin
アプリケーション
Stable or Transient mammalian expression
保存 & 配送
配送方法
Each tube contains lyophilized plasmid.
保存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

P38 Gamma/MAPK12 cDNA ORF ヌクレオチド配列およびアミノ酸配列に関する情報

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

P38 Gamma/MAPK12 cDNA ORF Clone, Human, untagged: 検証済の画像

P38 Gamma/MAPK12 cDNA ORF Clone, Human, untagged: 別名

ERK-6 cDNA ORF Clone, Human; ERK3 cDNA ORF Clone, Human; ERK6 cDNA ORF Clone, Human; MAPK12 cDNA ORF Clone, Human; P38GAMMA cDNA ORF Clone, Human; PRKM12 cDNA ORF Clone, Human; SAPK-3 cDNA ORF Clone, Human; SAPK3 cDNA ORF Clone, Human

P38 Gamma/MAPK12 背景情報

ERK3, also known as MAPK12 and p38-gamma, belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. ERK3 is highly expressed in skeletal muscle and heart. ERK3 is a serine/threonine kinase that acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 2 to 3 substrates each. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability, and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.
完全な名称
mitogen-activated protein kinase 12
Related Pathways
  • NF-kB (NFkB) Pathway
    NF-kB (NFkB) Pathway
  • TNF Signaling
    TNF Signaling
  • VEGF Signaling Pathway
    VEGF Signaling Pathway
  • T Cell Receptor Signaling Pathway
    T Cell Receptor Signaling Pathway
  • IL1 signaling pathway
    IL1 signaling pathway
  • IL17 signaling pathway
    IL17 signaling pathway
参考文献
  • Stiffler MA. et al., 2006, J Am Chem Soc. 128 (17): 5913-22.
  • Joneson T. et al., 1997, J Mol Med. 75 (8): 587-93.
  • Hou SW. et al., 2010, Cancer Res. 70 (7): 2901-10.
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