NEDD4 cDNA ORF Clone in Cloning Vector, Human

NEDD4 cDNA ORF Clone in Cloning Vector, Human: 製品情報

NCBI 参考シーケンス番号
2703 bp
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 2571T/G not causing the amino acid variation.
Full length Clone DNA of Human neural precursor cell expressed, developmentally down-regulated 4
SP6 and T7 or M13-47 and RV-M
The plasmid is confirmed by full-length sequencing.
保存 & 配送
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.

NEDD4 cDNA ORF ヌクレオチド配列およびアミノ酸配列に関する情報

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

NEDD4 cDNA ORF Clone in Cloning Vector, Human: 別名

NEDD4-1 cDNA ORF Clone, Human; RPF1 cDNA ORF Clone, Human

NEDD4 背景情報

Neural precursor cell expressed developmentally down-regulated protein 4 (NEDD4) is an E3 ligase that degrades multiple different proteins and plays an oncogenic role in human cancer. The Nedd4 family E3 ligases are key regulators of cell growth and proliferation and are often misregulated in human cancers and other diseases. The ligase activities of Nedd4 E3s are tightly controlled via auto-inhibition. Nedd4 deficiency promoted mouse death from sepsis and cell pyroptosis, resulting from non-canonical inflammasome activation. Furthermore, Nedd4 induced the K48-linked polyubiquitination and subsequent degradation of caspase-11 through the 26S proteasome. Meanwhile, caspase-11 (or caspase-4) reciprocally regulated the level of Nedd4 protein by cleavage. Thus, Nedd4 appears to have a key role in balancing the level of non-canonical inflammasome activation in response to gram-negative bacterial infection.
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
Related Pathways
  • Notch Signaling
    Notch Signaling
  • Zhu K, et al. (2017) Allosteric auto-inhibition and activation of the nedd4 family e3 ligase itch. EMBO Rep 18 (9): 1618-1630.
  • Zhang J, et al. (2019) Diosgenin inhibits the expression of nedd4 in prostate cancer cells. Am J Transl Res 11 (6): 3461-3471.
  • Liu Q, et al. (2019) E3 ubiquitin ligase nedd4 is a key negative regulator for non-canonical inflammasome activation. Cell Death Differ 26 (11): 2386-2399.
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