MTOR cDNA ORF Clone, Human, C-OFPSpark® tag

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MTOR cDNA ORF Clone, Human, C-OFPSpark® tag: 製品情報

遺伝子
Human
NCBI 参考シーケンス番号
遺伝子の長さ
7650 bp
シーケンスの特徴
Identical with the Gene Bank Ref. ID sequence.
製品の特徴
Full length Clone DNA of Human mechanistic target of rapamycin (serine/threonine kinase) with C terminal OFPSpark / RFP tag.
プラスミド
プロモーター
Enhanced CMV promoter
ベクター
制限部位
HindIII + NotI (6kb + 8.34kb)
タグシーケンス
OFPSpark Tag: GATAGCACTGAG……CACCTGTTCCAG
シークエンシングプライマー
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
品質管理
The plasmid is confirmed by full-length sequencing.
スクリーニング
細菌スクリーニング抵抗力
Kanamycin
細胞スクリーニング抵抗力
Hygromycin
アプリケーション
Stable or Transient mammalian expression
保存 & 配送
配送方法
Each tube contains lyophilized plasmid.
保存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

MTOR cDNA ORF ヌクレオチド配列およびアミノ酸配列に関する情報

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

MTOR cDNA ORF Clone, Human, C-OFPSpark® tag: 検証済の画像

MTOR cDNA ORF Clone, Human, C-OFPSpark® tag: 別名

FRAP cDNA ORF Clone, Human; FRAP1 cDNA ORF Clone, Human; FRAP2 cDNA ORF Clone, Human; RAFT1 cDNA ORF Clone, Human; RAPT1 cDNA ORF Clone, Human; SKS cDNA ORF Clone, Human

MTOR 背景情報

The protein encoded by MTOR gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.
完全な名称
mechanistic target of rapamycin (serine/threonine kinase)
研究分野
Related Pathways
  • EGFR Signaling Pathway
    EGFR Signaling Pathway
  • AKT Signaling Pathway
    AKT Signaling Pathway
  • AMPK Signaling Pathway
    AMPK Signaling Pathway
  • B Cell Receptor Signaling Pathway
    B Cell Receptor Signaling Pathway
  • Jak-Stat Signaling Pathway
    Jak-Stat Signaling Pathway
  • Autophagy Pathway
    Autophagy Pathway
  • Common G-Chain signaling pathway
    Common G-Chain signaling pathway
参考文献
  • Zhao J, Zhai B, Gygi SP, Goldberg AL. mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy. Proceedings of the National Academy of Sciences of the United States of America. 2015;112(52):15790-15797.
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