MMP-3 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag

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MMP-3 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag: 製品情報

遺伝子
Human
NCBI 参考シーケンス番号
遺伝子の長さ
1434 bp
シーケンスの特徴
Identical with the Gene Bank Ref. ID sequence (Nucleotide may contain silent mutation without changing amino acid sequence)
製品の特徴
Full length Clone DNA of Homo sapiens matrix metallopeptidase 3 (stromelysin 1, progelatinase).
プラスミド
プロモーター
Enhanced CMV mammalian cell promoter
ベクター
タグシーケンス
GFPSpark Tag Sequence: GTGAGCAAGGGC……GAGCTGTACAAG
シークエンシングプライマー
pLen-F(CTCGTTTAGTGAACCGTCAGAATT), pLen-R(GAACCGGAACCCTTAAACATGT)
品質管理
The plasmid is confirmed by full-length sequencing.
スクリーニング
細菌スクリーニング抵抗力
Ampicillin
保存 & 配送
配送方法
Each tube contains 10μg lyophilized plasmid
保存条件
The lyophilized plasmid can be stored at room temperature for three months

MMP-3 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag: 別名

CHDS6 cDNA ORF Clone, Human; MMP-3 cDNA ORF Clone, Human; SL-1 cDNA ORF Clone, Human; STMY cDNA ORF Clone, Human; STMY1 cDNA ORF Clone, Human; STR1 cDNA ORF Clone, Human

MMP-3 背景情報

Matrix metallopeptidase 3 (abbreviated as MMP3) is also known as stromelysin 1 and progelatinase. MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes including arthritis and metastasis. As a secreted zinc-dependent endopeptidase, MMP3 exerts its functions mainly in extracellular matrix. This protein is activated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMP3 plays a central role in degrading collagen types II, III, IV, IX, and X, proteoglycans, fibronectin, laminin, and elastin. In addition, MMP3 can also active other MMPs such as MMP1, MMP7, and MMP9, rendering MMP3 crucial in connective tissue remodeling. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.
完全な名称
matrix metallopeptidase 3
Related Pathways
  • IL17 signaling pathway
    IL17 signaling pathway
参考文献
  • Sternlicht MD, et al. 1999, The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Cell. 98(2): 137-46.
  • Yoon S, et al. (1999) Genetic analysis of MMP3, MMP9, and PAI-1 in Finnish patients with abdominal aortic or intracranial aneurysms. Biochem Biophys Res Commun. 265(2): 563-8.
  • Biondi ML, et al. (2000) MMP1 and MMP3 polymorphisms in promoter regions and cancer. Clin Chem. 46(12): 2023-4.
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