The plasmid is confirmed by full-length sequencing.
Stable or Transient mammalian expression
保存 & 配送
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
MMP-15/MT2-MMP cDNA ORF ヌクレオチド配列およびアミノ酸配列に関する情報
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
Membrane-type 2 matrix metalloproteinase (MT2-MMP; also known as MMP15) is a membrane-bound protease that degrades extracellular matrix and activates ProMMPs such as ProMMP-2. MMP15 is the membrane-type MMP (MT-MMP) which is a recently identified matrix metalloproteinase (MMP) capable of degrading all kinds of extracellular matrix proteins as well as numerous bioactive molecules. Matrix metalloproteinase 15 (MMP15) is the functional regulated gene of miR-339-5p in breast carcinoma. The MMP15 was identified to be a target of miR-339-5p. The level of MMP15 was negatively regulated by miR-339-5p whereas positively controlled by MAFG-AS1. Matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases, are involved in a variety of physiological and pathological processes. MMP7 and MMP15 were overexpressed in acute myeloid leukemia (AML) patients.
matrix metallopeptidase 15 (membrane-inserted)
Patterson RA, et al. (2013) Mt2-mmp expression during early avian morphogenesis. Anat Rec (Hoboken) 296 (1): 64-70.
Li H, et al. (2019) Lncrna mafg-as1 promotes the aggressiveness of breast carcinoma through regulating mir-339-5p/mmp15. Eur Rev Med Pharmacol Sci 23 (7): 2838-2846.
Kim OH, et al. (2019) Generation of mmp15b zebrafish mutant to investigate liver diseases. Dev Reprod 23 (4): 385-390.
Jia YC, et al. (2019) Lncrna mafg-as1 facilitates the migration and invasion of nsclc cell via sponging mir-339-5p from mmp15. Cell Biol Int 43 (4): 384-393.