MMP-15/MT2-MMP cDNA ORF Clone, Human, untagged

MMP-15/MT2-MMP cDNA ORF Clone, Human, untagged: 製品情報

遺伝子
Human
NCBI 参考シーケンス番号
遺伝子の長さ
2010 bp
シーケンスの特徴
Identical with the Gene Bank Ref. ID sequence except for two point mutations: 12 C/A, 222 T/C not causing the amino acid variation.
製品の特徴
Full length Clone DNA of Human matrix metallopeptidase 15 (membrane-inserted).
プラスミド
プロモーター
Enhanced CMV promoter
ベクター
制限部位
HindIII + XbaI (6.1kb + 2.01kb)
シークエンシングプライマー
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
品質管理
The plasmid is confirmed by full-length sequencing.
スクリーニング
細菌スクリーニング抵抗力
Ampicillin
細胞スクリーニング抵抗力
Hygromycin
アプリケーション
Stable or Transient mammalian expression
保存 & 配送
配送方法
Each tube contains lyophilized plasmid.
保存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

MMP-15/MT2-MMP cDNA ORF ヌクレオチド配列およびアミノ酸配列に関する情報

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

MMP-15/MT2-MMP cDNA ORF Clone, Human, untagged: 検証済の画像

MMP-15/MT2-MMP cDNA ORF Clone, Human, untagged: 別名

MT2-MMP cDNA ORF Clone, Human; MTMMP2 cDNA ORF Clone, Human; SMCP-2 cDNA ORF Clone, Human

MMP-15/MT2-MMP 背景情報

Membrane-type 2 matrix metalloproteinase (MT2-MMP; also known as MMP15) is a membrane-bound protease that degrades extracellular matrix and activates ProMMPs such as ProMMP-2. MMP15 is the membrane-type MMP (MT-MMP) which is a recently identified matrix metalloproteinase (MMP) capable of degrading all kinds of extracellular matrix proteins as well as numerous bioactive molecules. Matrix metalloproteinase 15 (MMP15) is the functional regulated gene of miR-339-5p in breast carcinoma. The MMP15 was identified to be a target of miR-339-5p. The level of MMP15 was negatively regulated by miR-339-5p whereas positively controlled by MAFG-AS1. Matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases, are involved in a variety of physiological and pathological processes. MMP7 and MMP15 were overexpressed in acute myeloid leukemia (AML) patients.
完全な名称
matrix metallopeptidase 15 (membrane-inserted)
参考文献
  • Patterson RA, et al. (2013) Mt2-mmp expression during early avian morphogenesis. Anat Rec (Hoboken) 296 (1): 64-70.
  • Li H, et al. (2019) Lncrna mafg-as1 promotes the aggressiveness of breast carcinoma through regulating mir-339-5p/mmp15. Eur Rev Med Pharmacol Sci 23 (7): 2838-2846.
  • Kim OH, et al. (2019) Generation of mmp15b zebrafish mutant to investigate liver diseases. Dev Reprod 23 (4): 385-390.
  • Jia YC, et al. (2019) Lncrna mafg-as1 facilitates the migration and invasion of nsclc cell via sponging mir-339-5p from mmp15. Cell Biol Int 43 (4): 384-393.
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