MMP-15/MT2-MMP cDNA ORF Clone, Human, C-His tag

MMP-15/MT2-MMP cDNA ORF Clone, Human, C-His tag: 製品情報

遺伝子
Human
NCBI 参考シーケンス番号
遺伝子の長さ
2010 bp
製品の特徴
Full length Clone DNA of Human matrix metallopeptidase 15 (membrane-inserted) with C terminal His tag.
プラスミド
プロモーター
Enhanced CMV promoter
ベクター
タグシーケンス
His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
シークエンシングプライマー
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
品質管理
The plasmid is confirmed by full-length sequencing.
スクリーニング
細菌スクリーニング抵抗力
Kanamycin
細胞スクリーニング抵抗力
Hygromycin
アプリケーション
Stable or Transient mammalian expression
保存 & 配送
配送方法
Each tube contains lyophilized plasmid.
保存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

MMP-15/MT2-MMP cDNA ORF Clone, Human, C-His tag: 別名

MT2-MMP cDNA ORF Clone, Human; MTMMP2 cDNA ORF Clone, Human; SMCP-2 cDNA ORF Clone, Human

MMP-15/MT2-MMP 背景情報

Membrane-type 2 matrix metalloproteinase (MT2-MMP; also known as MMP15) is a membrane-bound protease that degrades extracellular matrix and activates ProMMPs such as ProMMP-2. MMP15 is the membrane-type MMP (MT-MMP) which is a recently identified matrix metalloproteinase (MMP) capable of degrading all kinds of extracellular matrix proteins as well as numerous bioactive molecules. Matrix metalloproteinase 15 (MMP15) is the functional regulated gene of miR-339-5p in breast carcinoma. The MMP15 was identified to be a target of miR-339-5p. The level of MMP15 was negatively regulated by miR-339-5p whereas positively controlled by MAFG-AS1. Matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases, are involved in a variety of physiological and pathological processes. MMP7 and MMP15 were overexpressed in acute myeloid leukemia (AML) patients.
完全な名称
matrix metallopeptidase 15 (membrane-inserted)
参考文献
  • Patterson RA, et al. (2013) Mt2-mmp expression during early avian morphogenesis. Anat Rec (Hoboken) 296 (1): 64-70.
  • Li H, et al. (2019) Lncrna mafg-as1 promotes the aggressiveness of breast carcinoma through regulating mir-339-5p/mmp15. Eur Rev Med Pharmacol Sci 23 (7): 2838-2846.
  • Kim OH, et al. (2019) Generation of mmp15b zebrafish mutant to investigate liver diseases. Dev Reprod 23 (4): 385-390.
  • Jia YC, et al. (2019) Lncrna mafg-as1 facilitates the migration and invasion of nsclc cell via sponging mir-339-5p from mmp15. Cell Biol Int 43 (4): 384-393.
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