MFI2 cDNA ORF Clone, Human, untagged

MFI2 cDNA ORF Clone, Human, untagged: 製品情報

遺伝子
Human
NCBI 参考シーケンス番号
遺伝子の長さ
2217 bp
製品の特徴
Full length Clone DNA of Human antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
プラスミド
プロモーター
Enhanced CMV mammalian cell promoter
ベクター
シークエンシングプライマー
T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
品質管理
The plasmid is confirmed by full-length sequencing.
スクリーニング
細菌スクリーニング抵抗力
Ampicillin
細胞スクリーニング抵抗力
Hygromycin
アプリケーション
Stable or Transient mammalian expression
保存 & 配送
配送方法
Each tube contains lyophilized plasmid.
保存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

MFI2 cDNA ORF Clone, Human, untagged: 別名

CD228 cDNA ORF Clone, Human; MAP97 cDNA ORF Clone, Human; MTf cDNA ORF Clone, Human; MTF1 cDNA ORF Clone, Human

MFI2 背景情報

MELTF (Melanotransferrin, also known as MFI2) is a Protein Coding gene. The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. MELTF is broadly expressed in the salivary gland, kidney, and other tissues. The long non-coding RNA MFI2 antisense RNA is overexpressed in human cancer tissues and its increased expression is associated with the occurrence and metastasis of cancer. lncRNA MFI2 could promote proliferation and migration of osteosarcoma cells by regulating FOXP4 expression, which suggested critical roles of lncRNA MFI2 and FOXP4 in the occurrence and development of human osteosarcoma. Diseases associated with MELTF include Osteogenic Sarcoma and Melanotic Neuroectodermal Tumor.
完全な名称
melanotransferrin
参考文献
  • Richardson DR. (2000) The role of the membrane-bound tumour antigen, melanotransferrin (p97), in iron uptake by the human malignant melanoma cell. Eur J Biochem. 267(5): 1290-8.
  • Kim DK, et al. (2001) Serum melanotransferrin, p97 as a biochemical marker of Alzheimer's disease. Neuropsychopharmacology. 25(1): 84-90.
  • Rothenberger S, et al. (1996) Coincident expression and distribution of melanotransferrin and transferrin receptor in human brain capillary endothelium. Brain Res. 712(1): 117-21.
  • Baker EN, et al. (1992) Human melanotransferrin (p97) has only one functional iron-binding site. FEBS Lett. 298(2-3): 215-8.
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